BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) infection is associated with intensive care admissions, morbidity, and mortality. Our study aimed to determine the incidence, risk factors, and patient outcomes of CRE in the ICU units. METHODS: This was a retrospective matched case-control study of patients admitted to ICUs. Patients who have positive cultures of CRE and carbapenem-susceptible Enterobacteriaceae (CSE) were included in the study. Patients were randomly selected from a pool of CSE subjects in a ratio of 1:1 of CRE to CSE as control patients. RESULTS: The infection rate with CRE among all patients admitted to ICUs was 7.6% and the incidence of CRE infection was 5.6 per 1,000 person-day. The risk factors independently associated with CRE infection were: Higher Sequential Organ Failure Assessment (SOFA) and Nutrition Risk in Critically ill (NUTRIC) scores, prolonged ICU length of stay (LOS), previous surgery, dialysis and mechanical ventilation during ICU stay, and previous use of aminoglycoside and carbapenems. CONCLUSION: In this retrospective study, the incidence of CRE infection was relatively elevated in patients admitted to ICU. Patients with high SOFA and NUTRIC scores, prolonged ICU LOS, previous surgery, dialysis and mechanical ventilation, and prior aminoglycosides and carbapenems use, may have an increased risk of CRE infection.
BACKGROUND:Carbapenem-resistant Enterobacteriaceae (CRE) infection is associated with intensive care admissions, morbidity, and mortality. Our study aimed to determine the incidence, risk factors, and patient outcomes of CRE in the ICU units. METHODS: This was a retrospective matched case-control study of patients admitted to ICUs. Patients who have positive cultures of CRE and carbapenem-susceptible Enterobacteriaceae (CSE) were included in the study. Patients were randomly selected from a pool of CSE subjects in a ratio of 1:1 of CRE to CSE as control patients. RESULTS: The infection rate with CRE among all patients admitted to ICUs was 7.6% and the incidence of CRE infection was 5.6 per 1,000 person-day. The risk factors independently associated with CRE infection were: Higher Sequential Organ Failure Assessment (SOFA) and Nutrition Risk in Critically ill (NUTRIC) scores, prolonged ICU length of stay (LOS), previous surgery, dialysis and mechanical ventilation during ICU stay, and previous use of aminoglycoside and carbapenems. CONCLUSION: In this retrospective study, the incidence of CRE infection was relatively elevated in patients admitted to ICU. Patients with high SOFA and NUTRIC scores, prolonged ICU LOS, previous surgery, dialysis and mechanical ventilation, and prior aminoglycosides and carbapenems use, may have an increased risk of CRE infection.
Authors: Khalid Al Sulaiman; Ghazwa B Korayem; Khalid Eljaaly; Ali F Altebainawi; Omar Al Harbi; Hisham A Badreldin; Abdullah Al Harthi; Ghada Al Yousif; Ramesh Vishwakarma; Shorouq Albelwi; Rahaf Almutairi; Maha Almousa; Razan Alghamdi; Alaa Alhubaishi; Abdulrahman Alissa; Aisha Alharbi; Rahmah Algarni; Sarah Al Homaid; Khawla Al Qahtani; Nada Akhani; Abdulaleam Al Atassi; Ghassan Al Ghamdi; Ohoud Aljuhani Journal: Sci Rep Date: 2022-06-13 Impact factor: 4.996
Authors: Ohoud Aljuhani; Khalid Al Sulaiman; Adel Alshabasy; Khalid Eljaaly; Abdulrahman I Al Shaya; Haytham Noureldeen; Mohammed Aboudeif; Bodoor Al Dosari; Amina Alkhalaf; Ghazwa B Korayem; Muneera M Aleissa; Hisham A Badreldin; Shmeylan Al Harbi; Abdullah Alhammad; Ramesh Vishwakarma Journal: BMC Infect Dis Date: 2021-11-01 Impact factor: 3.090
Authors: Khalid Al Sulaiman; Ohoud Aljuhani; Ghazwa B Korayem; Ali F Altebainawi; Shmeylan Al Harbi; Abdulrahman Al Shaya; Hisham A Badreldin; Raed Kensara; Abdullah F Alharthi; Jahad Alghamdi; Ahad Alawad; Rand Alotaibi; Abdullah Kharbosh; Hessa Al Muqati; Abdulmohsen Alhuwahmel; Mohammed Almusallam; Ghada Albarrak; Ibrahim Al Sulaihim; Bader Alanazi; Bodoor S Al-Dosari; Ramesh Vishwakarma; Alawi S Alsaeedi; Ghassan Al Ghamdi; Hadeel Alkofide; Hasan M Al-Dorzi Journal: Front Public Health Date: 2022-08-11
Authors: Khalid Al Sulaiman; Ghazwa B Korayem; Ali F Altebainawi; Shmeylan Al Harbi; Abdulrahman Alissa; Abdullah Alharthi; Raed Kensara; Amjaad Alfahed; Ramesh Vishwakarma; Hussain Al Haji; Naif Almohaimid; Omar Al Zumai; Fahad Alrubayan; Abdulmajid Asiri; Nasser Alkahtani; Abdulaziz Alolayan; Samiah Alsohimi; Nawal Melibari; Alaa Almagthali; Seba Aljahdali; Abeer A Alenazi; Alawi S Alsaeedi; Ghassan Al Ghamdi; Omar Al Faris; Joud Alqahtani; Jalal Al Qahtani; Khalid A Alshammari; Khalil I Alshammari; Ohoud Aljuhani Journal: Crit Care Date: 2022-10-03 Impact factor: 19.334