Nicolai Haase1, Ronni Plovsing2, Steffen Christensen3, Lone Musaeus Poulsen4, Anne Craveiro Brøchner5, Bodil Steen Rasmussen6, Marie Helleberg7, Jens Ulrik Staehr Jensen8, Lars Peter Kloster Andersen9, Hanna Siegel10, Michael Ibsen11, Vibeke Jørgensen12, Robert Winding13, Susanne Iversen14, Henrik Planck Pedersen15, Jacob Madsen6, Christoffer Sølling16, Ricardo Sanchez Garcia17, Jens Michelsen18, Thomas Mohr10, Anne Mannering19, Ulrick Skipper Espelund20, Helle Bundgaard21, Lynge Kirkegaard22, Margit Smitt23, David Levarett Buck24, Niels-Erik Ribergaard25, Helle Scharling Pedersen26, Birgitte Viebaek Christensen27, Anders Perner1. 1. Department of Intensive Care, Rigshospitalet, Copenhagen, Denmark. 2. Department of Anesthesiology and Intensive Care, Hvidovre Hospital, Copenhagen, Denmark. 3. Department of Anesthesiology and Intensive Care, Århus University Hospital, Århus, Denmark. 4. Department of Anesthesiology and Intensive Care, Zealand University Hospital, Køge, Denmark. 5. Department of Anesthesiology and Intensive Care, Kolding Hospital, Kolding, Denmark. 6. Department of Anesthesiology and Intensive Care, Ålborg University Hospital, Ålborg, Denmark. 7. Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark. 8. Department of Respiratory Medicine, Herlev-Gentofte Hospital, Copenhagen, Denmark. 9. Department of Anesthesiology and Intensive Care, Bispebjerg Hospital, Copenhagen, Denmark. 10. Department of Anesthesiology and Intensive Care, Herlev-Gentofte Hospital, Copenhagen, Denmark. 11. Department of Anesthesiology and Intensive Care, North Zealand Hospital, Hillerød, Denmark. 12. Department of Cardiothoracic Anesthesiology, Rigshospitalet, Copenhagen, Denmark. 13. Department of Anesthesiology and Intensive Care, Herning Hospital, Herning, Denmark. 14. Department of Anesthesiology and Intensive Care, Slagelse Hospital, Slagelse, Denmark. 15. Department of Anesthesiology and Intensive Care, Zealand University Hospital, Roskilde, Denmark. 16. Department of Anesthesiology and Intensive Care, Viborg Hospital, Viborg, Denmark. 17. Department of Anesthesiology and Intensive Care, Esbjerg Hospital, Esbjerg, Denmark. 18. Department of Anesthesiology and Intensive Care, Odense University Hospital, Odense, Denmark. 19. Department of Anesthesiology and Intensive Care, Svendborg Hospital, Svendborg, Denmark. 20. Department of Anesthesiology and Intensive Care, Horsens Hospital, Horsens, Denmark. 21. Department of Anesthesiology and Intensive Care, Randers Hospital, Randers, Denmark. 22. Department of Anesthesiology and Intensive Care, Åbenrå Hospital, Åbenrå, Denmark. 23. Department of Neuroanesthesiology, Rigshospitalet, Copenhagen, Denmark. 24. Department of Anesthesiology and Intensive Care, Holbaek Hospital, Holbaek, Denmark. 25. Department of Anesthesiology and Intensive Care, Hjørring Hospital, Hjørring, Denmark. 26. Department of Anesthesiology and Intensive Care, Nykøbing Falster Hospital, Nykøbing Falster, Denmark. 27. Department of Anesthesiology and Intensive Care, Glostrup Hospital, Copenhagen, Denmark.
Abstract
BACKGROUND: Most data on intensive care unit (ICU) patients with COVID-19 originate in selected populations from stressed healthcare systems with shorter term follow-up. We present characteristics, interventions and longer term outcomes of the entire, unselected cohort of all ICU patients with COVID-19 in Denmark where the ICU capacity was not exceeded. METHODS: We identified all patients with SARS-CoV-2 admitted to any Danish ICU from 10 March to 19 May 2020 and registered demographics, chronic comorbidities, use of organ support, length of stay, and vital status from patient files. Risk factors for death were analyzed using adjusted Cox regression analysis. RESULTS: There were 323 ICU patients with confirmed COVID-19. Median age was 68 years, 74% were men, 50% had hypertension, 21% diabetes, and 20% chronic pulmonary disease; 29% had no chronic comorbidity. Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26%, and extra corporeal membrane oxygenation in 8%. ICU stay was median 13 days (IQR 6-22) and hospital stay 19 days (11-30). Median follow-up was 79 days. At end of follow-up, 118 had died (37%), 15 (4%) were still in hospital hereof 4 in ICU as of 16 June 2020. Risk factors for mortality included male gender, age, chronic pulmonary disease, active cancer, and number of co-morbidities. CONCLUSIONS: In this nationwide, population-based cohort of ICU patients with COVID-19, longer term survival was high despite high age and substantial use of organ support. Male gender, age, and chronic co-morbidities, in particular chronic pulmonary disease, were associated with increased risk of death.
BACKGROUND: Most data on intensive care unit (ICU) patients with COVID-19 originate in selected populations from stressed healthcare systems with shorter term follow-up. We present characteristics, interventions and longer term outcomes of the entire, unselected cohort of all ICU patients with COVID-19 in Denmark where the ICU capacity was not exceeded. METHODS: We identified all patients with SARS-CoV-2 admitted to any Danish ICU from 10 March to 19 May 2020 and registered demographics, chronic comorbidities, use of organ support, length of stay, and vital status from patient files. Risk factors for death were analyzed using adjusted Cox regression analysis. RESULTS: There were 323 ICU patients with confirmed COVID-19. Median age was 68 years, 74% were men, 50% had hypertension, 21% diabetes, and 20% chronic pulmonary disease; 29% had no chronic comorbidity. Invasive mechanical ventilation was used in 82%, vasopressors in 83%, renal replacement therapy in 26%, and extra corporeal membrane oxygenation in 8%. ICU stay was median 13 days (IQR 6-22) and hospital stay 19 days (11-30). Median follow-up was 79 days. At end of follow-up, 118 had died (37%), 15 (4%) were still in hospital hereof 4 in ICU as of 16 June 2020. Risk factors for mortality included male gender, age, chronic pulmonary disease, active cancer, and number of co-morbidities. CONCLUSIONS: In this nationwide, population-based cohort of ICU patients with COVID-19, longer term survival was high despite high age and substantial use of organ support. Male gender, age, and chronic co-morbidities, in particular chronic pulmonary disease, were associated with increased risk of death.
Authors: Vibe S Mikkelsen; Marie Helleberg; Nicolai Haase; Morten H Møller; Anders Granholm; Merete Storgaard; Andreas B Jonsson; Kristian Schønning; Nanna Reiter; Sigurður Þór Sigurðsson; Marianne Voldstedlund; Steffen Christensen; Anders Perner Journal: Acta Anaesthesiol Scand Date: 2021-06-23 Impact factor: 2.274
Authors: Jon H Laake; Eirik A Buanes; Milada C Småstuen; Reidar Kvåle; Brita F Olsen; Tone Rustøen; Kristian Strand; Vibecke Sørensen; Kristin Hofsø Journal: Acta Anaesthesiol Scand Date: 2021-02-27 Impact factor: 2.274
Authors: Fabio Silvio Taccone; Nina Van Goethem; Robby De Pauw; Xavier Wittebole; Koen Blot; Herman Van Oyen; Tinne Lernout; Marion Montourcy; Geert Meyfroidt; Dominique Van Beckhoven Journal: Lancet Reg Health Eur Date: 2020-12-23
Authors: Melchor Álvarez-Mon; Miguel A Ortega; Óscar Gasulla; Jordi Fortuny-Profitós; Ferran A Mazaira-Font; Pablo Saurina; Jorge Monserrat; María N Plana; Daniel Troncoso; José Sanz Moreno; Benjamin Muñoz; Alberto Arranz; Jose F Varona; Alejandro Lopez-Escobar; Angel Asúnsolo-Del Barco Journal: J Pers Med Date: 2021-01-08
Authors: Drago Plečko; Nicolas Bennett; Johan Mårtensson; Tariq A Dam; Robert Entjes; Thijs C D Rettig; Dave A Dongelmans; Age D Boelens; Sander Rigter; Stefaan H A Hendriks; Remko de Jong; Marlijn J A Kamps; Marco Peters; Attila Karakus; Diederik Gommers; Dharmanand Ramnarain; Evert-Jan Wils; Sefanja Achterberg; Ralph Nowitzky; Walter van den Tempel; Cornelis P C de Jager; Fleur G C A Nooteboom; Evelien Oostdijk; Peter Koetsier; Alexander D Cornet; Auke C Reidinga; Wouter de Ruijter; Rob J Bosman; Tim Frenzel; Louise C Urlings-Strop; Paul de Jong; Ellen G M Smit; Olaf L Cremer; D Jannet Mehagnoul-Schipper; Harald J Faber; Judith Lens; Gert B Brunnekreef; Barbara Festen-Spanjer; Tom Dormans; Daan P de Bruin; Robbert C A Lalisang; Sebastiaan J J Vonk; Martin E Haan; Lucas M Fleuren; Patrick J Thoral; Paul W G Elbers; Rinaldo Bellomo Journal: Acta Anaesthesiol Scand Date: 2021-10-15 Impact factor: 2.274