Hanna Kuzior1, Bernd L Fiebich2, Nizar M Yousif2, Soraya W Saliba2, Christiane Ziegler2, Kathrin Nickel1, Simon J Maier1, Patrick Süß3, Kimon Runge1, Miriam Matysik1, Rick Dersch4, Benjamin Berger4, Tilman Robinson4, Nils Venhoff5, Franziska Kessler6, Thomas Blank6, Katharina Domschke7, Ludger Tebartz van Elst1, Dominique Endres8. 1. Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. 2. Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. 3. Department of Molecular Neurology, University Hospital Erlangen, Erlangen, Germany. 4. Department for Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. 5. Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. 6. Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. 7. Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Center for Basics in Neuromodulation, Faculty of Medicine, University of Freiburg, Germany. 8. Section for Experimental Neuropsychiatry, Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Department of Psychiatry and Psychotherapy, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany. Electronic address: dominique.endres@uniklinik-freiburg.de.
Abstract
INTRODUCTION: Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression. MATERIALS AND METHODS: Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay. RESULTS: IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± 6.26 pg/ml versus 21.40 ± 7.96 pg/ml; p < .001). LIMITATIONS: The significance of the results is limited by the retrospective design and methodological aspects. DISCUSSION: The main findings of this study were significantly higher concentrations of IL-8 in the CSF of patients with unipolar depression than in the control group. The detection of high CSF IL-8 levels in this study supports the idea that inflammatory processes might play a role in the pathophysiology of a subgroup of patients with depression.
INTRODUCTION:Unipolar depression is a common and debilitating disorder. Immunological explanatory approaches have become increasingly important in recent years and can be studied particularly well in the cerebrospinal fluid (CSF). Previous studies discerned alterations in interleukin (IL)-6 and IL-8 levels; however, findings regarding IL-8 were partly contradictory. The aim of the present study was to investigate the concentrations of different cytokines and chemokines, focusing on IL-8, in the CSF of patients with unipolar depression. MATERIALS AND METHODS:Participants included 40 patients with unipolar depression and 39 mentally healthy controls with idiopathic intracranial hypertension. CSF cytokine levels were measured using a magnetic bead multiplexing immunoassay. RESULTS:IL-8 levels in the CSF of the patient group with depression were significantly higher than those in the control group (Mean ± SD: 38.44 ± 6.26 pg/ml versus 21.40 ± 7.96 pg/ml; p < .001). LIMITATIONS: The significance of the results is limited by the retrospective design and methodological aspects. DISCUSSION: The main findings of this study were significantly higher concentrations of IL-8 in the CSF of patients with unipolar depression than in the control group. The detection of high CSF IL-8 levels in this study supports the idea that inflammatory processes might play a role in the pathophysiology of a subgroup of patients with depression.
Authors: Martin Stangel; Klemens Ruprecht; Brigitte Wildemann; Sven Jarius; Florence Pache; Peter Körtvelyessy; Ilijas Jelčić; Mark Stettner; Diego Franciotta; Emanuela Keller; Bernhard Neumann; Marius Ringelstein; Makbule Senel; Axel Regeniter; Rea Kalantzis; Jan F Willms; Achim Berthele; Markus Busch; Marco Capobianco; Amanda Eisele; Ina Reichen; Rick Dersch; Sebastian Rauer; Katharina Sandner; Ilya Ayzenberg; Catharina C Gross; Harald Hegen; Michael Khalil; Ingo Kleiter; Thorsten Lenhard; Jürgen Haas; Orhan Aktas; Klemens Angstwurm; Christoph Kleinschnitz; Jan Lewerenz; Hayrettin Tumani; Friedemann Paul Journal: J Neuroinflammation Date: 2022-01-20 Impact factor: 8.322
Authors: Malek Ghandour; Jolin B Yamin; Judith E Arnetz; Mark A Lumley; Paul M Stemmer; Paul Burghardt; Hikmet Jamil; Bengt B Arnetz Journal: Cureus Date: 2022-08-21
Authors: Sophie Meixensberger; Hanna Kuzior; Bernd L Fiebich; Patrick Süß; Kimon Runge; Benjamin Berger; Kathrin Nickel; Dominik Denzel; Miriam A Schiele; Maike Michel; Simon Maier; Karl Bechter; Katharina Domschke; Ludger Tebartz van Elst; Dominique Endres Journal: Diagnostics (Basel) Date: 2021-06-22