BACKGROUND AND OBJECTIVE: Turbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors. METHODS: We retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital. RESULTS: Platelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG > 100 mmHg) and lower (LPPG < 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen. CONCLUSION: Shear stress affects PLT count, PDW, and fibrinogen in patients with AS.
BACKGROUND AND OBJECTIVE: Turbulent blood flow in patients with aortic valve stenosis (AS) results in morphological and functional changes in platelets and coagulation factors. The aim of this study is to determine how shear stress affects platelets and coagulation factors. METHODS: We retrospectively evaluated data from 78 patients who underwent AVR to treat AS between March 2008 and July 2017 at Kagoshima University Hospital. RESULTS: Platelet (PLT) count obviously decreased at three days after AVR, and increased above preoperative levels at the time of discharge. In contrast, platelet distribution width (PDW), mean platelet volume (MPV), and platelet large cell ratio (P-LCR) increased three days after AVR, then decreased to below preoperative levels. No differences were evident between groups with higher (HPPG > 100 mmHg) and lower (LPPG < 100 mmHg) peak pressure gradients (PPG) before AVR, whereas PLT count, PDW, MPV and P-LCR improved more in the HPPG group. Plateletcrit (PCT), which represents the total volume of platelets, increased after AVR due to decreased shear stress. High increasing rate of PCT was associated with lower PLT count, higher PDW and lower fibrinogen. CONCLUSION: Shear stress affects PLT count, PDW, and fibrinogen in patients with AS.
Authors: Nicolas Baeyens; Chirosree Bandyopadhyay; Brian G Coon; Sanguk Yun; Martin A Schwartz Journal: J Clin Invest Date: 2016-03-01 Impact factor: 14.808
Authors: Patrick Horn; Daniel Stern; Verena Veulemans; Christian Heiss; Tobias Zeus; Marc W Merx; Malte Kelm; Ralf Westenfeld Journal: EuroIntervention Date: 2015-04 Impact factor: 6.534
Authors: Philipp Diehl; Ferenc Nagy; Verena Sossong; Thomas Helbing; Friedhelm Beyersdorf; Manfred Olschewski; Christoph Bode; Martin Moser Journal: Thromb Haemost Date: 2008-04 Impact factor: 5.249
Authors: Koohyar Vahidkhah; Dan Cordasco; Mostafa Abbasi; Liang Ge; Elaine Tseng; Prosenjit Bagchi; Ali N Azadani Journal: Ann Biomed Eng Date: 2016-04-05 Impact factor: 3.934
Authors: Tamara Sastre-Oliva; Nerea Corbacho-Alonso; Diego Albo-Escalona; Juan A Lopez; Luis F Lopez-Almodovar; Jesús Vázquez; Luis R Padial; Laura Mourino-Alvarez; Maria G Barderas Journal: Antioxidants (Basel) Date: 2022-02-05