Literature DB >> 3292410

Mechanisms of transplantation tolerance induced by liver grafting in rats: involvement of serum factors in clonal deletion.

N Kamada1, R Sumimoto, A Baguerizo, A Yoshimatsu, K Teramoto, A Yamaguchi.   

Abstract

An adoptive transfer assay system was used to investigate the ability of serum from tolerant, liver-grafted rats to inactivate normal thoracic duct lymphocytes. PVG rats were rendered tolerant of DA alloantigens by liver grafting. Serum taken from such rats was used to treat normal PVG thoracic duct lymphocytes (TDL) in vitro and the transplant reactivity of the cells then tested in an adoptive transfer assay. Specific decreased responsiveness compared with TDL treated with normal sera was observed, indicating the functional elimination of alloreactive clones by agents in liver-graft serum.

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Year:  1988        PMID： 3292410      PMCID： PMC1384961     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  10 in total

1.  Magnitude of memory to the major histocompatibility complex.

Authors:  B M Hall; B J Roser; S E Dorsch
Journal:  Nature       Date:  1977-08-11       Impact factor: 49.962

2.  Prolonged lymphocytopenia in the rat. the immunological consequences of lymphocyte depletion following injection of 185 W tungsten trioxide into the spleen of lymph nodes.

Authors:  B Roser; W L Ford
Journal:  Aust J Exp Biol Med Sci       Date:  1972-04

Review 3.  The immunology of experimental liver transplantation in the rat.

Authors:  N Kamada
Journal:  Immunology       Date:  1985-07       Impact factor: 7.397

Review 4.  Antigen-reactive cell opsonization (ARCO) and its role in antibody-mediated immune suppression.

Authors:  I V Hutchinson
Journal:  Immunol Rev       Date:  1980       Impact factor: 12.988

Review 5.  Cells mediating allograft rejection.

Authors:  B M Hall; S E Dorsch
Journal:  Immunol Rev       Date:  1984       Impact factor: 12.988

6.  Mechanism of induction of passive enhancement. Evidence for an interaction of enhancing antibody with donor interstitial dendritic cells.

Authors:  D N Hart; J W Fabre
Journal:  Transplantation       Date:  1982-03       Impact factor: 4.939

7.  The adoptive transfer of first-set allograft responses by recirculating small lymphocytes in the rat.

Authors:  S Dorsch; B Roser
Journal:  Aust J Exp Biol Med Sci       Date:  1974-02

8.  Antigen-reactive cell opsonization (ARCO): a mechanism of immunological enhancement.

Authors:  I V Hutchinson; H Zola
Journal:  Transplantation       Date:  1977-06       Impact factor: 4.939

9.  Immunosuppressive activity of serum from liver-grafted rats. Passive enhancement of fully allogeneic heart grafts and induction of systemic tolerance.

Authors:  N Kamada; T Shinomiya; T Tamaki; K Ishiguro
Journal:  Transplantation       Date:  1986-12       Impact factor: 4.939

10.  Antigen-specific immunosuppression induced by liver transplantation in the rat.

Authors:  N Kamada; D G Wight
Journal:  Transplantation       Date:  1984-09       Impact factor: 4.939
  10 in total
  5 in total

1.  Expression, by functional proteomics, of spontaneous tolerance in rat orthotopic liver transplantation.

Authors:  Tai-Long Pan; Pei-Wen Wang; Chao-Chen Huang; Shigeru Goto; Chao-Long Chen
Journal:  Immunology       Date:  2004-09       Impact factor: 7.397

Review 2.  Towards the identification of biomarkers of transplantation tolerance.

Authors:  Laurence A Turka; Robert I Lechler
Journal:  Nat Rev Immunol       Date:  2009-07       Impact factor: 53.106

3.  FcR blocking activity in serum of actively enhanced rat renal allograft recipients due to IgG anti-class II MHC alloantibody.

Authors:  H E Marshall; E M Bolton; J A Gracie; J E Cocker; G P Sandilands; J A Bradley
Journal:  Immunology       Date:  1990-03       Impact factor: 7.397

4.  Liver graft induced donor specific unresponsiveness without class I and/or class II antigen differences.

Authors:  S Qian; H Sun; A J Demetris; F Fu; T E Starzl; J J Fung
Journal:  Transplant Proc       Date:  1993-02       Impact factor: 1.066

5.  The role of antibodies in liver graft-induced tolerance in mice: passive transfer of serum and effect of recipient B-cell depletion.

Authors:  U Dahmen; H Sun; Y Li; F Fu; A J Demetris; T E Starzl; S Qian; J J Fung
Journal:  Transplant Proc       Date:  1995-02       Impact factor: 1.066
  5 in total

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