Literature DB >> 3292324

Cyclosporin A suppresses insulin autoantibodies and heterologous insulin antibodies in type I diabetic children.

L Castaño1, C Boîtard, P F Bougnères.   

Abstract

We report that cyclosporin A (CsA) suppresses the insulin autoantibodies that are present before insulin therapy in the sera of one-third of studied type I (insulin-dependent) diabetic children. CsA also reversibly blocks the production of antibodies after exogenous insulin injection, whereas high titers of heterologous insulin antibody are observed in all type I patients not receiving CsA.

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Year:  1988        PMID： 3292324     DOI： 10.2337/diab.37.8.1049

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  4 in total

1.  T-cell response to proinsulin and insulin in type 1 and pretype 1 diabetes.

Authors:  D Dubois-LaForgue; J C Carel; P F Bougnères; J G Guillet; C Boitard
Journal:  J Clin Immunol       Date:  1999-03       Impact factor: 8.317

2.  Decreased insulin response to glucose in islet cell antibody-negative siblings of type 1 diabetic children.

Authors:  J C Carel; C Boitard; P F Bougnères
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

Review 3.  Targeting innate immunity to downmodulate adaptive immunity and reverse type 1 diabetes.

Authors:  Arata Itoh; William M Ridgway
Journal:  Immunotargets Ther       Date:  2017-05-19

4.  Exhausted-like CD8+ T cell phenotypes linked to C-peptide preservation in alefacept-treated T1D subjects.

Authors:  Kirsten E Diggins; Elisavet Serti; Virginia Muir; Mario Rosasco; TingTing Lu; Elisa Balmas; Gerald Nepom; S Alice Long; Peter S Linsley
Journal:  JCI Insight       Date:  2021-02-08
  4 in total

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