Literature DB >> 3292294

The Kluyveromyces lactis KEX1 gene encodes a subtilisin-type serine proteinase.

C Tanguy-Rougeau1, M Wésolowski-Louvel, H Fukuhara.   

Abstract

KEX1 is a chromosomal gene required for the production of the killer toxin encoded by the linear DNA plasmid pGKL-1 of Kluyveromyces lactis. The nucleotide sequence of the cloned KEX1 gene has been determined. The deduced structure of the KEX1 protein, 700 amino acids long, indicated that it contained an internal domain with a striking homology to the sequences of the subtilisin-type proteinases, and a probable transmembrane domain near the carboxyl terminus. The results confirm the hypothesis that the product of the gene KEX1 of K. lactis is a proteinase involved in the processing of the toxin precursor.

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Year:  1988        PMID： 3292294     DOI： 10.1016/0014-5793(88)80139-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  13 in total

1.  Expression and secretion of a thermostable bacterial xylanase in Kluyveromyces lactis.

Authors:  D J Walsh; P L Bergquist
Journal:  Appl Environ Microbiol       Date:  1997-08       Impact factor: 4.792

2.  A palindromic mutation of the linear killer plasmid k2 of yeast.

Authors:  M Wésolowski-Louvel; H Fukuhara
Journal:  Nucleic Acids Res       Date:  1990-08-25       Impact factor: 16.971

3.  cDNA structure, tissue distribution, and chromosomal localization of rat PC7, a novel mammalian proprotein convertase closest to yeast kexin-like proteinases.

Authors:  N G Seidah; J Hamelin; M Mamarbachi; W Dong; H Tardos; M Mbikay; M Chretien; R Day
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-16       Impact factor: 11.205

4.  Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes.

Authors:  W J van de Ven; J Voorberg; R Fontijn; H Pannekoek; A M van den Ouweland; H L van Duijnhoven; A J Roebroek; R J Siezen
Journal:  Mol Biol Rep       Date:  1990-11       Impact factor: 2.316

5.  Activation of the kexin from Schizosaccharomyces pombe requires internal cleavage of its initially cleaved prosequence.

Authors:  D Powner; J Davey
Journal:  Mol Cell Biol       Date:  1998-01       Impact factor: 4.272

Review 6.  Protein transport and compartmentation in yeast.

Authors:  J Horák
Journal:  Folia Microbiol (Praha)       Date:  1991       Impact factor: 2.099

7.  A phosphoglucose isomerase gene is involved in the Rag phenotype of the yeast Kluyveromyces lactis.

Authors:  P Goffrini; M Wésolowski-Louvel; I Ferrero
Journal:  Mol Gen Genet       Date:  1991-09

8.  Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole.

Authors:  C A Wilcox; K Redding; R Wright; R S Fuller
Journal:  Mol Biol Cell       Date:  1992-12       Impact factor: 4.138

9.  Kexin-like endoprotease KexB is required for N-glycan processing, morphogenesis and virulence in Aspergillus fumigatus.

Authors:  Jingyang Wang; Hui Zhou; Hua Lu; Ting Du; Yuanming Luo; Iain B H Wilson; Cheng Jin
Journal:  Fungal Genet Biol       Date:  2015-02-14       Impact factor: 3.495

10.  A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease.

Authors:  P Gluschankof; R S Fuller
Journal:  EMBO J       Date:  1994-05-15       Impact factor: 11.598
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