Yunyun Duan1, Jie Zhang1, Zhizheng Zhuo1, Jinli Ding1, Rongkai Ju2, Jiazheng Wang2, Tingting Ma1, Sven Haller3, Yong Liu4, Yaou Liu5. 1. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China. 2. Clinical Science, Philips Healthcare, Beijing, China. 3. Department of Imaging and Medical Informatics, University Hospitals of Geneva and Faculty of Medicine of the University of Geneva, Geneva, Switzerland. 4. Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China; Center for Excellence in Brain Science and Intelligence Technology, Institute of Automation, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China. 5. Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Tiantan Image Research Center, China National Clinical Research Center for Neurological Diseases, Beijing, China. Electronic address: liuyaou@bjtth.org.
Abstract
PURPOSE: To evaluate the clinical application of the accelerated 3D T1-weighted turbo field echo (T1W-TFE) using the compressed sensing-sensitivity encoding (CS-SENSE) and identify the appropriate acceleration factor. METHODS: 33 healthy controls (HC), 10 multiple sclerosis (MS) and 10 Alzheimer's disease (AD) patients were prospectively recruited. A conventional 3D T1W-TFE sequence and accelerated sequences with CS-SENSE factors of 3, 4.5, 6 and with SENSE factors of 3, 4.5 were acquired for all participants on a 3.0T MR system. The visual evaluation was independently assessed by two experienced radiologists. Quantitative image quality metrics and intraclass correlation coefficients (ICCs) between the conventional and the accelerated sequences were performed at the voxel level. Group comparisons were performed between HC and AD or MS patients. RESULTS: There were no significant differences in the visual image quality metrics between conventional sequence and CS-SENSE factor of 3. The sequences with CS-SENSE factor of 6 and SENSE factors of 3, 4.5 showed significantly decreased overall image quality. The ICC values based on the voxel level of each accelerated scan and conventional scan were high (>0.9, 85.2%). For different accelerated sequences, AD and MS patients showed consistent results with the conventional sequence in gray matter atrophy when compared to HC. CONCLUSIONS: CS-SENSE factor of 3 is the appropriate parameter to accelerate the 3D T1W-TFE (65% time reduction) with preserved visual image quality. The voxel-based analysis demonstrated high ICCs for brain volume measurements in the majority of brain regions, implying the feasibility of the accelerated technique.
PURPOSE: To evaluate the clinical application of the accelerated 3D T1-weighted turbo field echo (T1W-TFE) using the compressed sensing-sensitivity encoding (CS-SENSE) and identify the appropriate acceleration factor. METHODS: 33 healthy controls (HC), 10 multiple sclerosis (MS) and 10 Alzheimer's disease (AD) patients were prospectively recruited. A conventional 3D T1W-TFE sequence and accelerated sequences with CS-SENSE factors of 3, 4.5, 6 and with SENSE factors of 3, 4.5 were acquired for all participants on a 3.0T MR system. The visual evaluation was independently assessed by two experienced radiologists. Quantitative image quality metrics and intraclass correlation coefficients (ICCs) between the conventional and the accelerated sequences were performed at the voxel level. Group comparisons were performed between HC and AD or MS patients. RESULTS: There were no significant differences in the visual image quality metrics between conventional sequence and CS-SENSE factor of 3. The sequences with CS-SENSE factor of 6 and SENSE factors of 3, 4.5 showed significantly decreased overall image quality. The ICC values based on the voxel level of each accelerated scan and conventional scan were high (>0.9, 85.2%). For different accelerated sequences, AD and MS patients showed consistent results with the conventional sequence in gray matter atrophy when compared to HC. CONCLUSIONS: CS-SENSE factor of 3 is the appropriate parameter to accelerate the 3D T1W-TFE (65% time reduction) with preserved visual image quality. The voxel-based analysis demonstrated high ICCs for brain volume measurements in the majority of brain regions, implying the feasibility of the accelerated technique.