| Literature DB >> 32919570 |
Samah Attia Algharib1, Ali Dawood2, Kaixiang Zhou3, Dongmei Chen4, Chao Li3, Kuiyu Meng3, Muhammad Kashif Maa3, Saeed Ahmed3, Lingli Huang5, Shuyu Xie6.
Abstract
Due to the poor solubility and permeability of rifaximin (RFX), it is not effective against intracellular pathogens although it shows strong activity against most bacteria. To develop an effective mucoadhesive drug delivery system with a targeted release in bacterial infection site, RFX-loaded chitosan (CS)/carboxymethyl-chitosan (CMCS) nanogel was designed and systematically evaluated. FTIR, DSC, and XRD demonstrated that the nanogel was formed by interactions between the positively charged NH3+ on CS and CMCS, and the negatively charged COO on CMCS. RFX was encapsulated into the optimized nanogel in amorphous form. The nanogel was a uniform spherical shape with a mean diameter of 171.07 nm. It had excellent sustained release, strong mucin binding ability, and pH-responsive properties of quicker swelling and release at acidic pH. It showed low hemolytic ratio and high antioxidant activity. The present investigation indicated that the CS-nanogel could be potentially used as a promising bacterial responsiveness drug delivery system.Entities:
Keywords: Acetic acid; Bioadhesive; Carboxy methyl chitosan; Chitosan; DPPH; Mucin (from porcine stomach); Nanogel; Potassium bromide (KBr); Rifaximin; Tri polyphosphate; Triton X-100; pH-responsiveness
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Year: 2020 PMID： 32919570 DOI： 10.1016/j.carbpol.2020.116782
Source DB: PubMed Journal: Carbohydr Polym ISSN： 0144-8617 Impact factor: 9.381