Construction of Bridged Polycyclic Skeletons via Transition-Metal Catalyzed Carbon-Carbon Bond-Forming Reactions.

Transition-metal catalysis has become one of most important methods for constructing molecules with diverse architectures. Bridged polycyclic skeletons are often considered one of most challenging structures in organic synthesis. This Minireview summarizes the recent progress on synthesis of bridged polycyclic skeletons by transition-metal-catalyzed carbon-carbon bond-forming reaction. Four main ring-forming strategies including connection via olefin or carbonyl functionality, enolate intermediacy, C-H functionality, and aryl functionality are detailed and some effective methods are discussed with particular emphasis on reaction design and mechanism.