Seroepidemiology of bovine brucellosis in Colombia's preeminent dairy region, and its potential public health impact.

A cross-sectional study was conducted to determine the associated factors of brucellosis in Colombia's preeminent dairy region declared in quarantine. A total of 656 samples were collected from cows ≥ 2-year-old from 40 herds. Samples were screened by the Rose Bengal Plate Test, and the Fluorescence Polarized Assay test and Competitive ELISA were used as confirmatory tests. A cow was classified as positive if the screening and both confirmatory tests were positive. A herd was classified as positive if at least one cow was seropositive. The factors associated to seropositivity were tested using a logistic regression model with explanatory variables regarding cattle management, zootechnical parameters, and sanitary practices. The seroprevalence at the animal level was 6.6% (43/656) and at herd level 27.5% (11/40). In the model, five variables explained the animal cases: purchase or animal transfer between owner's farms (OR = 2.79, 95% CI 1.42, 5.49), history of abortion (OR = 4.22, 95% CI 1.91, 9.33), birth of weak calves (OR = 13.77, 95% CI 2.75, 68.91), use of a bull for mating (OR = 9.69, 95% CI 2.23, 42.18), and the vaccination in adulthood (OR = 3.03, 95% CI 1.04.8.78). In the model at the herd level, two variables explained the cases: birth of weak calves (OR = 9.60, 95% CI 1.54, 59.76) and purchase or animal transfer between owner's farms (OR = 7.22, 95% CI 1.03, 50.62). These results justify the need for a quarantine declaration in the region and the implementation of epidemiological studies as a public health measures used to combat outbreak.