OBJECTIVE: To assess the physiopathology of olfactory function loss (OFL) in patients with coronavirus disease 2019 (COVID-19), we evaluated the olfactory clefts (OC) on MRI during the early stage of the disease and 1 month later. METHODS: This was a prospective, monocentric, case-controlled study. Twenty severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infected patients with OFL were included and compared to 20 age-matched healthy controls. All infected patients underwent olfactory function assessment and 3T MRI, performed both at the early stage of the disease and at the 1-month follow-up. RESULTS: At the early stage, SARS-CoV2-infected patients had a mean olfactory score of 2.8 ± 2.7 (range 0-8), and MRI displayed a complete obstruction of the OC in 19 of 20 patients. Controls had normal olfactory scores and no obstruction of the OC on MRI. At the 1 month follow-up, the olfactory score had improved to 8.3 ± 1.9 (range 4-10) in patients, and only 7 of 20 patients still had an obstruction of the OC. There was a correlation between olfactory score and obstruction of the OC (p = 0.004). CONCLUSION: OFL in SARS-CoV2-infected patients is associated with a reversible obstruction of the OC.
OBJECTIVE: To assess the physiopathology of olfactory function loss (OFL) in patients with coronavirus disease 2019 (COVID-19), we evaluated the olfactory clefts (OC) on MRI during the early stage of the disease and 1 month later. METHODS: This was a prospective, monocentric, case-controlled study. Twenty severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)-infectedpatients with OFL were included and compared to 20 age-matched healthy controls. All infectedpatients underwent olfactory function assessment and 3T MRI, performed both at the early stage of the disease and at the 1-month follow-up. RESULTS: At the early stage, SARS-CoV2-infectedpatients had a mean olfactory score of 2.8 ± 2.7 (range 0-8), and MRI displayed a complete obstruction of the OC in 19 of 20 patients. Controls had normal olfactory scores and no obstruction of the OC on MRI. At the 1 month follow-up, the olfactory score had improved to 8.3 ± 1.9 (range 4-10) in patients, and only 7 of 20 patients still had an obstruction of the OC. There was a correlation between olfactory score and obstruction of the OC (p = 0.004). CONCLUSION: OFL in SARS-CoV2-infectedpatients is associated with a reversible obstruction of the OC.
Authors: Ludger Klimek; Jan Hagemann; Julia Döge; Laura Freudelsperger; Mandy Cuevas; Felix Klimek; Thomas Hummel Journal: Allergo J Int Date: 2022-06-20
Authors: A Boscutti; G Delvecchio; A Pigoni; G Cereda; V Ciappolino; M Bellani; P Fusar-Poli; P Brambilla Journal: Brain Behav Immun Health Date: 2021-05-18
Authors: Verena Rass; Ronny Beer; Alois Josef Schiefecker; Mario Kofler; Anna Lindner; Philipp Mahlknecht; Beatrice Heim; Victoria Limmert; Sabina Sahanic; Alex Pizzini; Thomas Sonnweber; Ivan Tancevski; Christoph Scherfler; Laura Zamarian; Rosa Bellmann-Weiler; Günter Weiss; Atbin Djamshidian; Stefan Kiechl; Klaus Seppi; Judith Loeffler-Ragg; Bettina Pfausler; Raimund Helbok Journal: Eur J Neurol Date: 2021-05-03 Impact factor: 6.288