Fabio C Torricelli1, Chad Reichard2, Manoj Monga3. 1. Department of Urology, University of Sao Paulo Medical School, São Paulo, SP, Brazil. 2. Department of Urology, University of Indiana, Indianapolis, IN, USA. 3. Department of Urology, University of California, 200 W. Arbor Drive, MC8897, San Diego, CA, 92103-8897, USA. endourol@yahoo.com.
Abstract
PURPOSE: To evaluate the impact of extensive surgery on urine profile, serum exams and stone composition of complicated IBD patients. METHODS: Patients with IBD and a history of total proctocolectomy (TPC) with fecal diversion (end ileostomy or ileal pouch anal anastomosis-IPAA) were selected. Only patients with at least one complete 24-h urine profile were included. A case-control study was performed selecting patients with kidney stone disease in a random way who had also at least on complete 24-h urine profile. Case and controls were matched for age, gender, and body mass index (BMI). Groups were compared to urine profile, serum exams and stone composition. RESULTS: Sixty-eight patients were enrolled in this study, 34 patients with IBD who underwent TPC and had diagnosis of kidney stones and 34 matched patients with only kidney stones. IBD patients had a significantly lower urine volume, urine citrate and urine sodium. Regarding serum exams, only serum bicarbonate was statistically significant lower. In both groups, calcium oxalate stone was the most common. CONCLUSION: Patients with IBD with TPC and kidney stones have a low urine volume and low urine citrate as main risk factors for kidney stone formation. As seen in the general population, calcium oxalate is the most common stone composition.
PURPOSE: To evaluate the impact of extensive surgery on urine profile, serum exams and stone composition of complicated IBDpatients. METHODS:Patients with IBD and a history of total proctocolectomy (TPC) with fecal diversion (end ileostomy or ileal pouch anal anastomosis-IPAA) were selected. Only patients with at least one complete 24-h urine profile were included. A case-control study was performed selecting patients with kidney stone disease in a random way who had also at least on complete 24-h urine profile. Case and controls were matched for age, gender, and body mass index (BMI). Groups were compared to urine profile, serum exams and stone composition. RESULTS: Sixty-eight patients were enrolled in this study, 34 patients with IBD who underwent TPC and had diagnosis of kidney stones and 34 matched patients with only kidney stones. IBDpatients had a significantly lower urine volume, urine citrate and urine sodium. Regarding serum exams, only serum bicarbonate was statistically significant lower. In both groups, calcium oxalate stone was the most common. CONCLUSION:Patients with IBD with TPC and kidney stones have a low urine volume and low urine citrate as main risk factors for kidney stone formation. As seen in the general population, calcium oxalate is the most common stone composition.
Authors: Parth M Patel; Alexander M Kandabarow; Eseosa Aiwerioghene; Enrique Blanco-Martinez; Spencer Hart; David J Leehey; Ahmer Farooq; Kristin G Baldea; Thomas M T Turk Journal: Int Urol Nephrol Date: 2020-11-18 Impact factor: 2.370