Annalisa Chiari1, Giulia Vinceti1,2,3, Giorgia Adani2,3, Manuela Tondelli4, Chiara Galli4,5, Luigi Fiondella1,2, Manuela Costa6, Maria A Molinari4, Tommaso Filippini2,3, Giovanna Zamboni1,2,3,7, Marco Vinceti2,8. 1. U.O. di Neurologia, Azienda Ospedaliero Universitaria di Modena, Modena, Italy. 2. Dipartimento di Scienze Biomediche, Metaboliche e Neuroscienze, Università di Modena e Reggio Emilia, Modena, Italy. 3. Centro Interdipartimentale di Neuroscienze e Neurotecnologie, Università di Modena e Reggio Emilia, Modena, Italy. 4. Dipartimento di cure primarie, AUSL Modena, Modena, Italy. 5. NeuroFARBA, Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università degli Studi di Firenze, Italy. 6. Neurologia Ospedale di Carpi, AUSL Modena, Modena, Italy. 7. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. 8. Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
Abstract
INTRODUCTION: Patients with early onset dementia (EOD), defined as dementia with symptom onset at age <65, frequently present with atypical syndromes. However, the epidemiology of different EOD presentations, including variants of Alzheimer's disease (AD) and frontotemporal dementia (FTD), has never been investigated all together in a population-based study. Epidemiologic data of all-cause EOD are also scarce. METHODS: We investigated EOD epidemiology by identifying patients with EOD seen in the extended network of dementia services of the Modena province, Northern Italy (≈700,000 inhabitants) from 2006 to 2019. RESULTS: In the population age 30 to 64, incidence was 13.2 per 100,000/year, based on 160 new cases from January 2016 to June 2019, and prevalence 74.3 per 100,000 on June 30, 2019. The most frequent phenotypes were the amnestic variant of AD and behavioral variant of FTD. DISCUSSION: EOD affects a significant number of people. Amnestic AD is the most frequent clinical presentation in this understudied segment of the dementia population.
INTRODUCTION:Patients with early onset dementia (EOD), defined as dementia with symptom onset at age <65, frequently present with atypical syndromes. However, the epidemiology of different EOD presentations, including variants of Alzheimer's disease (AD) and frontotemporal dementia (FTD), has never been investigated all together in a population-based study. Epidemiologic data of all-cause EOD are also scarce. METHODS: We investigated EOD epidemiology by identifying patients with EOD seen in the extended network of dementia services of the Modena province, Northern Italy (≈700,000 inhabitants) from 2006 to 2019. RESULTS: In the population age 30 to 64, incidence was 13.2 per 100,000/year, based on 160 new cases from January 2016 to June 2019, and prevalence 74.3 per 100,000 on June 30, 2019. The most frequent phenotypes were the amnestic variant of AD and behavioral variant of FTD. DISCUSSION: EOD affects a significant number of people. Amnestic AD is the most frequent clinical presentation in this understudied segment of the dementia population.
Authors: Barbara Borroni; Caroline Graff; Orla Hardiman; Albert C Ludolph; Fermin Moreno; Markus Otto; Marco Piccininni; Anne M Remes; James B Rowe; Harro Seelaar; Elka Stefanova; Latchezar Traykov; Giancarlo Logroscino Journal: Alzheimers Dement Date: 2021-08-02 Impact factor: 16.655