Literature DB >> 32914794

How trimerization of CTR1 N-terminal model peptides tunes Cu-binding and redox-chemistry.

Thibaut Galler1, Vincent Lebrun1, Laurent Raibaut1, Peter Faller1, Nina E Wezynfeld2.   

Abstract

Employing peptide-based models of copper transporter 1 (CTR1), we show that the trimeric arrangement of its N-terminus tunes its reactivity with Cu, promoting Cu(ii) reduction and stabilizing Cu(i). Hence, the employed multimeric models of CTR1 provide an important contribution to studies on early steps of Cu uptake by cells.

Entities:  

Mesh：

Substances：

Year:  2020        PMID： 32914794     DOI： 10.1039/d0cc04693k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Multinuclear Metal-Binding Ability of the N-Terminal Region of Human Copper Transporter Ctr1: Dependence Upon pH and Metal Oxidation State.

Authors:  Maria Incoronata Nardella; Mariagrazia Fortino; Alessandra Barbanente; Giovanni Natile; Adriana Pietropaolo; Fabio Arnesano
Journal:  Front Mol Biosci       Date:  2022-05-05

2.  Secretion and uptake of copper via a small copper carrier in blood fluid.

Authors:  B D Gioilli; T Z Kidane; H Fieten; M Tellez; M Dalphin; A Nguyen; K Nguyen; M C Linder
Journal:  Metallomics       Date:  2022-03-25       Impact factor: 4.526

3.  The prognostic value and immune landscape of a cuproptosis-related lncRNA signature in head and neck squamous cell carcinoma.

Authors:  Yao Jun Li; Hai Yan Li; Quan Zhang; Sheng Li Wei
Journal:  Front Genet       Date:  2022-07-22       Impact factor: 4.772

4.  A Deeper Insight in Metal Binding to the hCtr1 N-terminus Fragment: Affinity, Speciation and Binding Mode of Binuclear Cu2+ and Mononuclear Ag+ Complex Species.

Authors:  Antonio Magrì; Giovanni Tabbì; Irina Naletova; Francesco Attanasio; Giuseppe Arena; Enrico Rizzarelli
Journal:  Int J Mol Sci       Date:  2022-03-08       Impact factor: 5.923
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.