| Literature DB >> 32913074 |
Kathryn Demanelis1, Farzana Jasmine1, Lin S Chen1, Meytal Chernoff1, Lin Tong1, Dayana Delgado1, Chenan Zhang1, Justin Shinkle1, Mekala Sabarinathan1, Hannah Lin1, Eduardo Ramirez1, Meritxell Oliva1,2, Sarah Kim-Hellmuth3,4,5, Barbara E Stranger2,6, Tsung-Po Lai7, Abraham Aviv7, Kristin G Ardlie8, François Aguet8, Habibul Ahsan1,9,10,11, Jennifer A Doherty12, Muhammad G Kibriya1, Brandon L Pierce13,9,10.
Abstract
Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across tissue types, positive correlation among tissue types, and associations with age and ancestry. We show that genetic variation affects TL in multiple tissue types and that TL may mediate the effect of age on gene expression. Our results provide the foundational knowledge regarding TL in healthy tissues that is needed to interpret epidemiological studies of TL and human health.Entities:
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Year: 2020 PMID： 32913074 DOI： 10.1126/science.aaz6876
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728