Stroke and COVID19: Not only a large-vessel disease.

Recent evidence has underlined the association between large-vessel stroke and COVID-19, probably due to a proinflammatory and prothrombotic microenvironment induced by SARS-CoV-2. Here, we report the case of a young fit woman affected by COVID-19 without any flu-like symptom, who suffered from speech disorder and left hemiparesis. Brain magnetic resonance evidenced two small acute brain infarctions in right perirolandic cortex without signs of previous ischemic lesions and hemorrhagic infarction. Diagnostic workup excluded cardiac embolic sources, acquired and inherited thrombophilia or autoimmune diseases. Two positive nasopharyngeal swab tests and high titers of serum specific IgA/IgM confirmed COVID-19 diagnosis. In our case stroke seems to be the only manifestation of SARS-COV-2 infection. Therefore the hypothesis of an underlying viral infection, as COVID-19, should be investigated in all the cases of small vessel cryptogenic stroke.

A 49-year-old women, scrub nurse in a COVID-19 hospital, was admitted to the Emergency Department for sudden onset of speech disorder and left hemiparesis with no fever, cough or wheezing. The neurological examination showed dysarthria, left facial weakness, left hemiparesis and hemianesthesia with National Institutes of Health Stroke Scale score (NIHSS) of 7. Brain angiography CT ruled out parenchymal lesions and large vessel occlusion (LVO). The patient received intravenous alteplase with improvement of neurological symptoms (NIHSS=1). Since she was positive for SARS-CoV-2 by RT-PCR from nasopharyngeal swab, the patient was transferred to COVID-19 subintensive Unit. Complete blood count revealed lymphocytosis (4.09 × 10^9/L) while systemic inflammatory and prothrombotic factors were normal. Furthermore, an EEG registration evidenced no irritative anomalies. Chest x-ray and CT did not show interstitial lung involvement.

SARS-COV-2 infection was confirmed by high titers of serum specific IgA/IgM and by the second positive nasopharyngeal swab sample.

Brain magnetic resonance imaging revealed two small cortical acute ischemic lesions in the right pre and postcentral gyrus, without signs of previous ischemic lesions and hemorrhagic infarction (Fig. 1 ). Cardiac workup consisting of electrocardiogram, cardiac telemetry monitoring, transthoracic and transesophageal echocardiography excluded arrhythmias, cardiac source of emboli, or patent foramen ovale. Serological testing for malignancy, thrombophilia and autoimmune diseases were negative.

Fig. 1

An axial section of diffusion-weighted (Panel A), Apparent diffusion coefficient (ADC) (Panel B), Fluid attenuation inversion recovery (FLAIR) (Panel C) and Susceptibility-weighted Angiography (SWAN) (Panel D) images of the brain shows two small acute brain infarctions (arrows) in right perirolandic cortex without signs of previous ischemic lesions and hemorrhagic infarction.

After two consecutive negative swab she was discharged with a diagnosis of COVID-19 related cryptogenic stroke.

Our report describes the case of a young fit woman without cerebrovascular risk factors or family history of neurological diseases who developed a cryptogenic stroke.

Although the relationship between viral infection and ischemic stroke is well-established, the pathogenic mechanism in the induction of cerebrovascular diseases is still debated. SARS-COV-2 seems to be able to create a pro-inflammatory microenvironment and to induce a prothrombotic state, predisposing to thrombogenesis and LVO stroke. , In our patient we did not detect any alteration of serum inflammation markers, , such as D-dimer, fibrinogen, C-reactive protein, erythrocyte sedimentation rate. Therefore, it is possible to hypothesize that SARS-COV-2 might penetrate the endothelial cells of the arterioles in the cerebral cortex inducing direct or immuno-mediated damage, without inducing a systemic response. This hypothesis is supported by the absence, in our patient, of flu or systemic symptoms, being stroke the only manifestation of COVID-19. In conclusion, the search for underlying viral infection such as COVID-19 should be investigated in all the cases of small vessel cryptogenic stroke.