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Literature DB >> 32910666

Direct Chiral ¹⁹F NMR Analysis of Fluorine-Containing Analytes and Its Application to Simultaneous Chiral Analysis.

Abstract

We have demonstrated the efficient chiral analysis of fluorine-containing compounds by 19F NMR spectroscopy. The highly sensitive fluorine nucleus allowed chiral analysis of complex mixtures and even asymmetric reaction mixtures of multisubstrates. A single 19F NMR experiment was sufficient to determine the enantiomeric excesses and yields of the five products simultaneously.

Entities: Chemical

Year: 2020 PMID： 32910666 DOI： 10.1021/acs.orglett.0c02620

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

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Cited

4 in total

1. Screening for generality in asymmetric catalysis.

Authors: Corin C Wagen; Spencer E McMinn; Eugene E Kwan; Eric N Jacobsen
Journal: Nature Date: 2022-09-01 Impact factor: 69.504

2. Enantioselective Bifunctional Ammonium Salt-Catalyzed Syntheses of 3-CF₃S-, 3-RS-, and 3-F-Substituted Isoindolinones.

Authors: Andreas Eitzinger; Jan Otevrel; Victoria Haider; Antonio Macchia; Antonio Massa; Kirill Faust; Bernhard Spingler; Albrecht Berkessel; Mario Waser
Journal: Adv Synth Catal Date: 2021-02-17 Impact factor: 5.837

3. Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted ¹⁹F NMR Spectroscopy.

Authors: Svitlana Kulyk; Susan M De Paul; Matthew A Marx; Torren M Peakman; Christopher R Smith
Journal: ACS Omega Date: 2022-08-31

4. A simple protocol for determination of enantiopurity of amines using BINOL derivatives as chiral solvating agents via ¹H- and ¹⁹F-NMR spectroscopic analysis.

Authors: Pooja Chaudhary; Geeta Devi Yadav; Surendra Singh
Journal: RSC Adv Date: 2022-09-08 Impact factor: 4.036

4 in total

Direct Chiral 19F NMR Analysis of Fluorine-Containing Analytes and Its Application to Simultaneous Chiral Analysis.

1. Screening for generality in asymmetric catalysis.

2. Enantioselective Bifunctional Ammonium Salt-Catalyzed Syntheses of 3-CF3S-, 3-RS-, and 3-F-Substituted Isoindolinones.

3. Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted 19F NMR Spectroscopy.

4. A simple protocol for determination of enantiopurity of amines using BINOL derivatives as chiral solvating agents via 1H- and 19F-NMR spectroscopic analysis.

Direct Chiral ¹⁹F NMR Analysis of Fluorine-Containing Analytes and Its Application to Simultaneous Chiral Analysis.

2. Enantioselective Bifunctional Ammonium Salt-Catalyzed Syntheses of 3-CF₃S-, 3-RS-, and 3-F-Substituted Isoindolinones.

3. Atropisomeric Racemization Kinetics of MRTX1719 Using Chiral Solvating Agent-Assisted ¹⁹F NMR Spectroscopy.

4. A simple protocol for determination of enantiopurity of amines using BINOL derivatives as chiral solvating agents via ¹H- and ¹⁹F-NMR spectroscopic analysis.