Literature DB >> 32910664

Biosynthetic Gene Cluster for Asperterpenols A and B and the Cyclization Mechanism of Asperterpenol A Synthase.

Zhiyang Quan1, Jeroen S Dickschat1.   

Abstract

The biosynthetic gene cluster for the sesterterpenoids asperterpenols A and B from Aspergillus calidoustus CBS121601 is described. The cluster contains two genes, acldAS for a chimeric sesterterpene synthase and acldA-P450 for a cytochrome P450 monooxygenase. The cyclization mechanism of the asperterpenol A synthase, catalyzing the formation of a unique sesterterpene with a 6/6/8/5 tetracyclic ring system, was studied using isotopically labeled terpene precursors.

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Year:  2020        PMID： 32910664     DOI： 10.1021/acs.orglett.0c02748

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach.

Authors:  Lan Jiang; Huanting Yang; Xue Zhang; Xiaoying Li; Kangjie Lv; Weiyan Zhang; Guoliang Zhu; Chengwei Liu; Yongheng Wang; Tom Hsiang; Lixin Zhang; Xueting Liu
Journal:  Appl Microbiol Biotechnol       Date:  2022-08-30       Impact factor: 5.560

2.  Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement.

Authors:  David C Miller; Ravi G Lal; Luca A Marchetti; Frances H Arnold
Journal:  J Am Chem Soc       Date:  2022-03-08       Impact factor: 16.383

3.  The Biosynthesis and Transport of Ophiobolins in Aspergillus ustus 094102.

Authors:  Jingjing Yan; Jiamin Pang; Jianjia Liang; Wulin Yu; Xuequn Liao; Ayikaimaier Aobulikasimu; Xinrui Yi; Yapeng Yin; Zixin Deng; Kui Hong
Journal:  Int J Mol Sci       Date:  2022-02-08       Impact factor: 5.923

4.  Enzymatic Synthesis of Variediene Analogs.

Authors:  Lin-Fu Liang; Jeroen S Dickschat
Journal:  Chemistry       Date:  2022-02-09       Impact factor: 5.020

5.  Norditerpenoids biosynthesized by variediene synthase-associated P450 machinery along with modifications by the host cell Aspergillus oryzae.

Authors:  Lan Jiang; Kangjie Lv; Guoliang Zhu; Zhi Lin; Xue Zhang; Cuiping Xing; Huanting Yang; Weiyan Zhang; Zhixin Wang; Chengwei Liu; Xudong Qu; Tom Hsiang; Lixin Zhang; Xueting Liu
Journal:  Synth Syst Biotechnol       Date:  2022-08-23

6.  Mechanism of the Bifunctional Multiple Product Sesterterpene Synthase AcAS from Aspergillus calidoustus.

Authors:  Zhiyang Quan; Anwei Hou; Bernd Goldfuss; Jeroen S Dickschat
Journal:  Angew Chem Int Ed Engl       Date:  2022-02-04       Impact factor: 16.823
  6 in total

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