Sijia Chen1,2, Graham Pawelec3,4, Stella Trompet1, David Goldeck3,5, Laust H Mortensen6, P Eline Slagboom7, Kaare Christensen8, Jacobijn Gussekloo1,9, Patricia Kearney10, Brendan M Buckley11, Ian Ford12, J Wouter Jukema13, Rudi G J Westendorp1,14,15, Andrea B Maier16,17. 1. Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, the Netherlands. 2. Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands. 3. Department of Immunology, University of Tübingen, Tübingen, Germany. 4. Health Sciences North Research Institute, Sudbury, Ontario, Canada. 5. Fairfax Centre, Kidlington, United Kingdom. 6. Methods and Analysis, Statistics Denmark, Copenhagen, Denmark. 7. Section of Molecular Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands. 8. Danish Aging Research Center, University of Southern Denmark, Odense, Denmark. 9. Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands. 10. Department of Epidemiology and Public Health, University College Cork, Cork, Ireland. 11. Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland. 12. Robertson Center for Biostatistics, University of Glasgow, United Kingdom. 13. Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands. 14. Leyden Academy on Vitality and Ageing, Leiden, the Netherlands. 15. Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 16. Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, University of Melbourne, Melbourne, Australia. 17. Department of Human Movement Sciences, @AgeAmsterdam, Amsterdam Movement Sciences, Vrije University, Amsterdam, the Netherlands.
Abstract
BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. CONCLUSIONS: CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.
BACKGROUND: Whether latent cytomegalovirus (CMV) infection in older adults has any substantial health consequences is unclear. Here, we sought associations between CMV-seropositivity and IgG titer with all-cause and cardiovascular mortality in 5 longitudinal cohorts. METHODS: Leiden Longevity Study, Prospective Study of Pravastatin in the Elderly at Risk, Longitudinal Study of Aging Danish Twins, and Leiden 85-plus Study were assessed at median (2.8-11.4 years) follow-up . Cox regression and random effects meta-analysis were used to estimate mortality risk dependent on CMV serostatus and/or IgG antibody titer, in quartiles after adjusting for confounders. RESULTS: CMV-seropositivity was seen in 47%-79% of 10 122 white community-dwelling adults aged 59-93 years. Of these, 3519 had died on follow-up (579 from cardiovascular disease). CMV seropositivity was not associated with all-cause (hazard ratio [HR], 1.05; 95% confidence interval [CI], .97-1.14) or cardiovascular mortality (HR, 0.97; 95% CI, .83-1.13). Subjects in the highest CMV IgG quartile group had increased all-cause mortality relative to CMV-seronegatives (HR, 1.16; 95% CI, 1.04-1.29) but this association lost significance after adjustment for confounders (HR, 1.13; 95% CI, .99-1.29). The lack of increased mortality risk was confirmed in subanalyses. CONCLUSIONS:CMV infection is not associated with all-cause or cardiovascular mortality in white community-dwelling older adults.
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