Kyoko Miura1,2,3, Mandy Way4,5, Zainab Jiyad4,6, Louise Marquart5, Elsemieke I Plasmeijer4,7, Scott Campbell8, Nicole Isbel8, Jonathan Fawcett9, Lisa E Ferguson4, Marcia Davis4, David C Whiteman4, H Peter Soyer10,11, Peter O'Rourke5, Adèle C Green4,12. 1. Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD, Australia. Kyoko.Miura@qimrberghofer.edu.au. 2. School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. Kyoko.Miura@qimrberghofer.edu.au. 3. School of Public Health and Social Work, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia. Kyoko.Miura@qimrberghofer.edu.au. 4. Population Health Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD, Australia. 5. Statistics Unit, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia. 6. Institute of Cardiovascular and Cell Sciences (Dermatology Unit), St George's University of London, London, UK. 7. The Netherlands Cancer Institute, Amsterdam, The Netherlands. 8. Department of Nephrology, University of Queensland at Princess Alexandra Hospital, Brisbane, QLD, Australia. 9. Queensland Liver Transplant Service, University of Queensland, Princess Alexandra Hospital, Brisbane, QLD, Australia. 10. Dermatology Research Centre, The University of Queensland, The University of Queensland Diamantina Institute, Woolloongabba, QLD, Australia. 11. Department of Dermatology, Princess Alexandra Hospital, Brisbane, QLD, Australia. 12. CRUK Manchester Institute and Faculty of Biology, Medicine and Health, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK.
Abstract
PURPOSE: Organ transplant recipients have over 100-fold higher risk of developing skin cancer than the general population and are in need of further preventive strategies. We assessed the possible preventive effects of omega-3 polyunsaturated fatty acid (PUFA) intake from food on the two main skin cancers, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in kidney and liver transplant recipients. METHODS: Adult kidney or liver transplant recipients transplanted for at least 1 year and at high risk of skin cancer were recruited from the main transplant hospital in Queensland, 2012-2014 and followed until mid-2016. We estimated their dietary total long-chain omega-3 PUFAs and α-linolenic acid intakes at baseline using a food frequency questionnaire and ranked PUFA intakes as low, medium, or high. Relative risks (RRsadj) of skin cancer adjusted for confounding factors with 95% confidence intervals (CIs) were calculated. RESULTS: There were 449 transplant recipients (mean age, 55 years; 286 (64%) male). During follow-up, 149 (33%) patients developed SCC (median 2/person; range 1-40) and 134 (30%), BCC. Transplant recipients with high total long-chain omega-3 PUFA compared with low intakes showed substantially reduced SCC tumour risk (RRadj 0.33, 95% CI 0.18-0.60), and those with high α-linolenic acid intakes experienced significantly fewer BCCs (RRadj 0.40, 95% CI 0.22-0.74). No other significant associations were seen. CONCLUSION: Among organ transplant recipients, relatively high intakes of long-chain omega-3 PUFAs and of α-linolenic acid may reduce risks of SCC and BCC, respectively.
PURPOSE: Organ transplant recipients have over 100-fold higher risk of developing skin cancer than the general population and are in need of further preventive strategies. We assessed the possible preventive effects of omega-3 polyunsaturated fatty acid (PUFA) intake from food on the two main skin cancers, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in kidney and liver transplant recipients. METHODS: Adult kidney or liver transplant recipients transplanted for at least 1 year and at high risk of skin cancer were recruited from the main transplant hospital in Queensland, 2012-2014 and followed until mid-2016. We estimated their dietary total long-chain omega-3 PUFAs and α-linolenic acid intakes at baseline using a food frequency questionnaire and ranked PUFA intakes as low, medium, or high. Relative risks (RRsadj) of skin cancer adjusted for confounding factors with 95% confidence intervals (CIs) were calculated. RESULTS: There were 449 transplant recipients (mean age, 55 years; 286 (64%) male). During follow-up, 149 (33%) patients developed SCC (median 2/person; range 1-40) and 134 (30%), BCC. Transplant recipients with high total long-chain omega-3 PUFA compared with low intakes showed substantially reduced SCC tumour risk (RRadj 0.33, 95% CI 0.18-0.60), and those with high α-linolenic acid intakes experienced significantly fewer BCCs (RRadj 0.40, 95% CI 0.22-0.74). No other significant associations were seen. CONCLUSION: Among organ transplant recipients, relatively high intakes of long-chain omega-3 PUFAs and of α-linolenic acid may reduce risks of SCC and BCC, respectively.
Authors: Michelle R Iannacone; Nirmala Pandeya; Nicole Isbel; Scott Campbell; Jonathan Fawcett; H Peter Soyer; Lisa Ferguson; Marcia Davis; David C Whiteman; Adèle C Green Journal: Dermatology Date: 2015-09-29 Impact factor: 5.366
Authors: Elsemieke I Plasmeijer; Zainab Jiyad; Mandy Way; Louise Marquart; Kyoko Miura; Scott Campbell; Nikky Isbel; Jonathan Fawcett; Lisa E Ferguson; Marcia Davis; David C Whiteman; H Peter Soyer; Peter O'Rourke; Adèle C Green Journal: Acta Derm Venereol Date: 2019-09-01 Impact factor: 4.437
Authors: Britta Krynitz; Gustaf Edgren; Bernt Lindelöf; Eva Baecklund; Christina Brattström; Henryk Wilczek; Karin E Smedby Journal: Int J Cancer Date: 2012-08-28 Impact factor: 7.396
Authors: M M Madeleine; N S Patel; E I Plasmeijer; E A Engels; J N Bouwes Bavinck; A E Toland; A C Green Journal: Br J Dermatol Date: 2017-10-10 Impact factor: 9.302