Karen Van Mechelen1,2, Marisse Meeus3, Veerle Matheeussen4,5, Gilbert Donders6,7, Yves Jacquemyn6, Ludo Mahieu3. 1. Department of Pediatrics, Division Neonatology, University Hospital Antwerp, University of Antwerp, Antwerp, Belgium. karen.v.mechelen@gmail.com. 2. Department of Pediatrics, Division of Neonatology, Maastricht University Medical Center, Maastricht, The Netherlands. karen.v.mechelen@gmail.com. 3. Department of Pediatrics, Division Neonatology, University Hospital Antwerp, University of Antwerp, Antwerp, Belgium. 4. Laboratory of Clinical Microbiology, University Hospital Antwerp, Antwerp, Belgium. 5. Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium. 6. Department of Obstetrics and Gynecology, University Hospital Antwerp, University of Antwerp, Antwerp, Belgium. 7. Global Health Institute GHI and ASTARC, University of Antwerp, Antwerp, Belgium.
Abstract
OBJECTIVE: We investigated the association between maternal cervicovaginal cultures, its antibiotic treatment, and neonatal outcome. STUDY DESIGN: This retrospective cohort study enrolled 480 neonates born prior to 32 weeks' gestation. They were divided into groups according to maternal cervicovaginal culture results. Multivariate logistic regression analysis was used to predict neonatal outcome based on maternal culture results, adjusted for perinatal risk factors and neonatal morbidities. RESULT: Maternal cervicovaginal Ureaplasma colonization was independently associated with bronchopulmonary dysplasia at 36 weeks (BPD) (OR 8.34; 95% CI 1.21-57.45). In neonates with and without maternal cervicovaginal Ureaplasma colonization BPD occurred in 12.3% and 3.8%, respectively. Maternal colonization with other microorganisms was associated with a higher neonatal mortality (p = 0.002), lower gestational age (p = 0.026), and birth weight (p = 0.036). CONCLUSIONS: This study underscores the role of the maternal cervicovaginal microbiome as a predictor of neonatal outcome. Cervicovaginal Ureaplasma colonization seems not to be an innocent bystander in the multifactorial etiology of BPD.
OBJECTIVE: We investigated the association between maternal cervicovaginal cultures, its antibiotic treatment, and neonatal outcome. STUDY DESIGN: This retrospective cohort study enrolled 480 neonates born prior to 32 weeks' gestation. They were divided into groups according to maternal cervicovaginal culture results. Multivariate logistic regression analysis was used to predict neonatal outcome based on maternal culture results, adjusted for perinatal risk factors and neonatal morbidities. RESULT: Maternal cervicovaginal Ureaplasma colonization was independently associated with bronchopulmonary dysplasia at 36 weeks (BPD) (OR 8.34; 95% CI 1.21-57.45). In neonates with and without maternal cervicovaginal Ureaplasma colonization BPD occurred in 12.3% and 3.8%, respectively. Maternal colonization with other microorganisms was associated with a higher neonatal mortality (p = 0.002), lower gestational age (p = 0.026), and birth weight (p = 0.036). CONCLUSIONS: This study underscores the role of the maternal cervicovaginal microbiome as a predictor of neonatal outcome. Cervicovaginal Ureaplasma colonization seems not to be an innocent bystander in the multifactorial etiology of BPD.
Authors: J C Carey; W C Blackwelder; R P Nugent; M A Matteson; A V Rao; D A Eschenbach; M L Lee; P J Rettig; J A Regan; K L Geromanos Journal: Am J Obstet Gynecol Date: 1991-03 Impact factor: 8.661