| Literature DB >> 32905785 |
Hankyul Kwak1, Wuhyun Koh2, Sangwoo Kim1, Kiyeong Song1, Jeong-Im Shin3, Jung Moo Lee4, Elliot H Lee1, Jin Young Bae5, Go Eun Ha1, Ju-Eun Oh6, Yongmin Mason Park2, Sunpil Kim7, Jiesi Feng8, Seung Eun Lee9, Ji Won Choi10, Ki Hun Kim11, Yoo Sung Kim12, Junsung Woo13, Dongsu Lee1, Taehwang Son14, Soon Woo Kwon15, Ki Duk Park16, Bo-Eun Yoon12, Jaeick Lee11, Yulong Li17, Hyunbeom Lee6, Yong Chul Bae5, C Justin Lee18, Eunji Cheong19.
Abstract
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.Entities:
Keywords: Best1; aldehyde dehydrogenase; astrocyte; diamine oxidase; sensory acuity; tactile discrimination; temporal fidelity; thalamus; tonic GABA; tonic inhibition
Year: 2020 PMID： 32905785 DOI： 10.1016/j.neuron.2020.08.013
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173