Tuba Talo Yıldırım1, Serkan Dündar1, Alihan Bozoğlan1, Tahir Karaman2, Onur Evren Kahraman3, Erhan Cahit Özcan4. 1. Department of Periodontology, Faculty of Dentistry, Firat University, Elazig, Turkey. 2. Department of Prosthodontics, Faculty of Dentistry, Firat University, Elazig, Turkey. 3. Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Firat University, Elazig, Turkey. 4. Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Firat University, Elazig, Turkey.
Abstract
OBJECTIVES: In this research it was aimed to that evaluation of the effects of systemic metformin administration on the periimplant bone tissue response of TiAl6Va4 implants in experimental rat model. MATERIALS AND METHOD: Firstly TiAl6Va4 implants were inserted surgically in the metaphyseal part of the tibial bone and after, the rats were randomly separated into two groups: Controls (CNT) (n = 10) and Metformin group (M) (n = 10). No additional treatment was applied to the controls during the 4-week experimental period. Rats received 40 mg/kg metformin in every day during the four week experimental period in M group. At the end of the 28-day follow-up period, the TiAl6Va4 implants with surrounding bone were used for the histopathologic analysis. To analysis of the datas between M and CNT Student-T Test was used. RESULT: Periimplant bone tissue filling ratios (%) were detected higher in M group compared with the CNT (P < 0.05). CONCLUSION: Systemic administration of metformin may increases titanium implant osseointegration in non-diabetic rats.
OBJECTIVES: In this research it was aimed to that evaluation of the effects of systemic metformin administration on the periimplant bone tissue response of TiAl6Va4 implants in experimental rat model. MATERIALS AND METHOD: Firstly TiAl6Va4 implants were inserted surgically in the metaphyseal part of the tibial bone and after, the rats were randomly separated into two groups: Controls (CNT) (n = 10) and Metformin group (M) (n = 10). No additional treatment was applied to the controls during the 4-week experimental period. Rats received 40 mg/kg metformin in every day during the four week experimental period in M group. At the end of the 28-day follow-up period, the TiAl6Va4 implants with surrounding bone were used for the histopathologic analysis. To analysis of the datas between M and CNT Student-T Test was used. RESULT: Periimplant bone tissue filling ratios (%) were detected higher in M group compared with the CNT (P < 0.05). CONCLUSION: Systemic administration of metformin may increases titanium implant osseointegration in non-diabetic rats.
Authors: Francisco Humberto Nociti Júnior; João Batista Cesar Neto; Marcelo Diniz Carvalho; Enilson Antonio Sallum; Antonio Wilson Sallum Journal: J Periodontol Date: 2002-09 Impact factor: 6.993
Authors: Kimberly Ann S Inouye; Frederick C Bisch; Mohammed E Elsalanty; Ibrahim Zakhary; Rania M Khashaba; James L Borke Journal: Implant Dent Date: 2014-06 Impact factor: 2.454
Authors: Paula G F P Oliveira; Paulo G Coelho; Edmara T P Bergamo; Lukasz Witek; Cristine A Borges; Fábio B Bezerra; Arthur B Novaes; Sergio L S Souza Journal: Materials (Basel) Date: 2020-12-13 Impact factor: 3.623