Literature DB >> 3290384

Interleukin 1 potentiates the lethal effect of tumor necrosis factor alpha/cachectin in mice.

A Waage1, T Espevik.   

Abstract

Human rIL-1 alpha and human rIL-1 beta were examined for their ability to potentiate the lethal and hypothermic effects of mouse rTNF-alpha in mice. The LD50 of rTNF-alpha was 1.5 micrograms/mouse, whereas the LD50 of rTNF-alpha was reduced to 0.4 micrograms/mouse and 0.5 micrograms/mouse when rTNF-alpha was administered in combination with a nonlethal dose of rIL-1 alpha or rIL-1 beta, respectively. A similar rTNF-alpha enhancing effect of the rIL-1 was observed on the temperature response. The results show that the rIL-1 markedly potentiate the effects of rTNF-alpha on lethality and temperature in mice, and support our suggestion that TNF-alpha and IL-1 may have synergistic lethal effect in human septic shock.

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Year:  1988        PMID： 3290384      PMCID： PMC2189698          DOI： 10.1084/jem.167.6.1987

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  19 in total

Review 1.  The role of cachectin/TNF in endotoxic shock and cachexia.

Authors:  A Cerami; B Beutler
Journal:  Immunol Today       Date:  1988-01

2.  Synergistic anti-proliferative activity of interleukin 1 and tumor necrosis factor.

Authors:  V Ruggiero; C Baglioni
Journal:  J Immunol       Date:  1987-02-01       Impact factor: 5.422

3.  Purification and characterization of human interleukin-1 beta expressed in recombinant Escherichia coli.

Authors:  P Wingfield; M Payton; J Tavernier; M Barnes; A Shaw; K Rose; M G Simona; S Demczuk; K Williamson; J M Dayer
Journal:  Eur J Biochem       Date:  1986-11-03

4.  Properties of a specific interleukin 1 (IL 1) receptor on human Epstein Barr virus-transformed B lymphocytes: identity of the receptor for IL 1-alpha and IL 1-beta.

Authors:  K Matsushima; T Akahoshi; M Yamada; Y Furutani; J J Oppenheim
Journal:  J Immunol       Date:  1986-06-15       Impact factor: 5.422

5.  Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

Authors:  D Pennica; J S Hayflick; T S Bringman; M A Palladino; D V Goeddel
Journal:  Proc Natl Acad Sci U S A       Date:  1985-09       Impact factor: 11.205

6.  Shock and tissue injury induced by recombinant human cachectin.

Authors:  K J Tracey; B Beutler; S F Lowry; J Merryweather; S Wolpe; I W Milsark; R J Hariri; T J Fahey; A Zentella; J D Albert
Journal:  Science       Date:  1986-10-24       Impact factor: 47.728

7.  Association between tumour necrosis factor in serum and fatal outcome in patients with meningococcal disease.

Authors:  A Waage; A Halstensen; T Espevik
Journal:  Lancet       Date:  1987-02-14       Impact factor: 79.321

8.  Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

Authors:  M P Bevilacqua; J S Pober; G R Majeau; W Fiers; R S Cotran; M A Gimbrone
Journal:  Proc Natl Acad Sci U S A       Date:  1986-06       Impact factor: 11.205

9.  An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin 1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.

Authors:  T H Pohlman; K A Stanness; P G Beatty; H D Ochs; J M Harlan
Journal:  J Immunol       Date:  1986-06-15       Impact factor: 5.422

10.  Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Authors:  C A Dinarello; J G Cannon; S M Wolff; H A Bernheim; B Beutler; A Cerami; I S Figari; M A Palladino; J V O'Connor
Journal:  J Exp Med       Date:  1986-06-01       Impact factor: 14.307
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  52 in total

1.  Neutralization of microcystin shock in mice by tumor necrosis factor alpha antiserum.

Authors:  Y Nakano; M Shirai; N Mori; M Nakano
Journal:  Appl Environ Microbiol       Date:  1991-01       Impact factor: 4.792

Review 2.  Regulatory mechanisms of antitumor T cell responses in the tumor-bearing state.

Authors:  H Fujiwara; T Hamaoka
Journal:  Immunol Res       Date:  1995       Impact factor: 2.829

3.  Altered in vivo activity of liposome-incorporated lipopolysaccharide and lipid A.

Authors:  J Dijkstra; J W Mellors; J L Ryan
Journal:  Infect Immun       Date:  1989-11       Impact factor: 3.441

4.  Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury.

Authors:  A Seekamp; J S Warren; D G Remick; G O Till; P A Ward
Journal:  Am J Pathol       Date:  1993-08       Impact factor: 4.307

5.  Cerebrospinal fluid levels of interleukin-6 and interleukin-12 in children with meningitis.

Authors:  Chia-Chang Hsieh; Jen-Her Lu; Shu-Jen Chen; Cheng-Chou Lan; Wen-Chi Chow; Ren-Bin Tang
Journal:  Childs Nerv Syst       Date:  2008-09-25       Impact factor: 1.475

6.  Protection against endotoxic shock and lipopolysaccharide-induced local inflammation by tetracycline: correlation with inhibition of cytokine secretion.

Authors:  L Shapira; W A Soskolne; Y Houri; V Barak; A Halabi; A Stabholz
Journal:  Infect Immun       Date:  1996-03       Impact factor: 3.441

7.  Endotoxin administration to humans primes alveolar macrophages for increased production of inflammatory mediators.

Authors:  P D Smith; A F Suffredini; J B Allen; L M Wahl; J E Parrillo; S M Wahl
Journal:  J Clin Immunol       Date:  1994-03       Impact factor: 8.317

8.  Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid.

Authors:  G C Rice; P A Brown; R J Nelson; J A Bianco; J W Singer; S Bursten
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-26       Impact factor: 11.205

9.  Role of tumor necrosis factor-alpha in lipopolysaccharide-induced pathologic alterations.

Authors:  D G Remick; R M Strieter; M K Eskandari; D T Nguyen; M A Genord; C L Raiford; S L Kunkel
Journal:  Am J Pathol       Date:  1990-01       Impact factor: 4.307

10.  The role of inflammatory mediators in the pathogenesis of otitis media and sequelae.

Authors:  Steven K Juhn; Min-Kyo Jung; Mark D Hoffman; Brian R Drew; Diego A Preciado; Nicholas J Sausen; Timothy T K Jung; Bo Hyung Kim; Sang-Yoo Park; Jizhen Lin; Frank G Ondrey; David R Mains; Tina Huang
Journal:  Clin Exp Otorhinolaryngol       Date:  2008-09-30       Impact factor: 3.372
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