Alena Liskova1, Lenka Koklesova1, Marek Samec1, Elizabeth Varghese2, Mariam Abotaleb2, Samson Mathews Samuel2, Karel Smejkal3, Kamil Biringer1, Martin Petras4, Dana Blahutova5, Ondrej Bugos6, Martin Pec7, Marian Adamkov8, Dietrich Büsselberg9, Rachele Ciccocioppo10, Mariusz Adamek11, Luis Rodrigo12, Martin Caprnda13, Peter Kruzliak14,15, Peter Kubatka16. 1. Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia. 2. Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar. 3. Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic. 4. Biomedical Center Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. 5. Department of Biology and Ecology, Faculty of Education, Catholic University in Ruzomberok, Ruzomberok, Slovakia. 6. Lambda Life JSC., Bratislava, Slovakia. 7. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01, Martin, Slovakia. 8. Department of Histology and Embryology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovakia. 9. Department of Physiology and Biophysics, Weill Cornell Medicine in Qatar, Education City, Qatar Foundation, Doha, 24144, Qatar. dib2015@qatar-med.cornell.edu. 10. Gastroenterology Unit, Department of Medicine, Azienda Ospedaliera Universitaria Integrata Policlinico GB Rossi, University of Verona, Verona, Italy. 11. Department of Thoracic Surgery, Faculty of Medicine and Dentistry, Medical University of Silesia, Katowice, Poland. 12. Faculty of Medicine, University of Oviedo, Central University Hospital of Asturias (HUCA), Oviedo, Spain. 13. 1st Department of Internal Medicine, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovakia. 14. 2nd Department of Surgery, Faculty of Medicine, Masaryk University, Pekarska 53, 656 91, Brno, Czech Republic. kruzliakpeter@gmail.com. 15. St. Anne's University Hospital, Brno, Czech Republic. kruzliakpeter@gmail.com. 16. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01, Martin, Slovakia. peter.kubatka@uniba.sk.
Abstract
PURPOSE: The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. METHODS: This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. RESULTS AND CONCLUSION: Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
PURPOSE: The formation of new blood vessels from previous ones, angiogenesis, is critical in tissue repair, expansion or remodeling in physiological processes and in various pathologies including cancer. Despite that, the development of anti-angiogenic drugs has great potential as the treatment of cancer faces many problems such as development of the resistance to treatment or an improperly selected therapy approach. An evaluation of predictive markers in personalized medicine could significantly improve treatment outcomes in many patients. METHODS: This comprehensive review emphasizes the anticancer potential of flavonoids mediated by their anti-angiogenic efficacy evaluated in current preclinical and clinical cancer research. RESULTS AND CONCLUSION:Flavonoids are important groups of phytochemicals present in common diet. Flavonoids show significant anticancer effects. The anti-angiogenic effects of flavonoids are currently a widely discussed topic of preclinical cancer research. Flavonoids are able to regulate the process of tumor angiogenesis through modulation of signaling molecules such as VEGF, MMPs, ILs, HIF or others. However, the evaluation of the anti-angiogenic potential of flavonoids within the clinical studies is not frequently discussed and is still of significant scientific interest.
Authors: Lenka Koklesova; Alena Liskova; Marek Samec; Kevin Zhai; Mariam Abotaleb; Milad Ashrafizadeh; Aranka Brockmueller; Mehdi Shakibaei; Kamil Biringer; Ondrej Bugos; Masoud Najafi; Olga Golubnitschaja; Dietrich Büsselberg; Peter Kubatka Journal: Biomolecules Date: 2020-12-10
Authors: Marek Samec; Alena Liskova; Lenka Koklesova; Sandra Mersakova; Jan Strnadel; Karol Kajo; Martin Pec; Kevin Zhai; Karel Smejkal; Sepideh Mirzaei; Kiavash Hushmandi; Milad Ashrafizadeh; Luciano Saso; Aranka Brockmueller; Mehdi Shakibaei; Dietrich Büsselberg; Peter Kubatka Journal: Cancers (Basel) Date: 2021-01-03 Impact factor: 6.639
Authors: Alena Liskova; Marek Samec; Lenka Koklesova; Samson M Samuel; Kevin Zhai; Raghad Khalid Al-Ishaq; Mariam Abotaleb; Vladimir Nosal; Karol Kajo; Milad Ashrafizadeh; Ali Zarrabi; Aranka Brockmueller; Mehdi Shakibaei; Peter Sabaka; Ioana Mozos; David Ullrich; Robert Prosecky; Giampiero La Rocca; Martin Caprnda; Dietrich Büsselberg; Luis Rodrigo; Peter Kruzliak; Peter Kubatka Journal: Biomed Pharmacother Date: 2021-02-25 Impact factor: 7.419
Authors: Olga Golubnitschaja; Peter Kubatka; Alena Mazurakova; Marek Samec; Abdullah Alajati; Frank A Giordano; Vincenzo Costigliola; Jörg Ellinger; Manuel Ritter Journal: Cancers (Basel) Date: 2022-01-28 Impact factor: 6.639
Authors: Alena Mazurakova; Marek Samec; Lenka Koklesova; Kamil Biringer; Erik Kudela; Raghad Khalid Al-Ishaq; Martin Pec; Frank A Giordano; Dietrich Büsselberg; Peter Kubatka; Olga Golubnitschaja Journal: EPMA J Date: 2022-07-08 Impact factor: 8.836
Authors: Peter Kubatka; Alena Mazurakova; Marek Samec; Lenka Koklesova; Kevin Zhai; Raghad Al-Ishaq; Karol Kajo; Kamil Biringer; Desanka Vybohova; Aranka Brockmueller; Martin Pec; Mehdi Shakibaei; Frank A Giordano; Dietrich Büsselberg; Olga Golubnitschaja Journal: EPMA J Date: 2021-10-06 Impact factor: 6.543