Zhenxing Wei1, Kunpeng Chang2, Chongsheng Fan2. 1. Department of Otorhinolaryngology-Head and Neck Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Middle No. 288 Zhongzhou Road, Luoyang, 471000, Henan, China. wzxmax79@163.com. 2. Department of Otorhinolaryngology-Head and Neck Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Middle No. 288 Zhongzhou Road, Luoyang, 471000, Henan, China.
Abstract
PURPOSE: To clarify the association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) and sudden sensorineural hearing loss (SSNHL). METHODS: A systematic literature search of related studies up to August 30, 2019 in the PubMed and Embase databases was performed, and the results were displayed by odds ratios (ORs), and their 95% confidence intervals (CIs) were assessed using the STATA12.0 software using an allele model and a recessive model. RESULTS: Three eligible studies covering 519 subjects (241 cases, 278 controls) were identified. No statistically significant association was detected between the 4G/5G polymorphism and SSNHL in any model (allele model: 5G vs. 4G, OR = 0.952, 95% CI = 0.765-1.185, P = 0.662; recessive model: 5G/5G vs. 4G/5G + 4G/4G, OR = 0.841, 95% CI = 0.415-1.704, P = 0.631). CONCLUSIONS: There is no statistically significant association between the 4G/5G polymorphism of PAI-1 gene and SSNHL in the Caucasian population, and well-designed studies covering more patients and institutions should be conducted.
PURPOSE: To clarify the association between the 4G/5G polymorphism of plasminogen activator inhibitor-1 (PAI-1) and sudden sensorineural hearing loss (SSNHL). METHODS: A systematic literature search of related studies up to August 30, 2019 in the PubMed and Embase databases was performed, and the results were displayed by odds ratios (ORs), and their 95% confidence intervals (CIs) were assessed using the STATA12.0 software using an allele model and a recessive model. RESULTS: Three eligible studies covering 519 subjects (241 cases, 278 controls) were identified. No statistically significant association was detected between the 4G/5G polymorphism and SSNHL in any model (allele model: 5G vs. 4G, OR = 0.952, 95% CI = 0.765-1.185, P = 0.662; recessive model: 5G/5G vs. 4G/5G + 4G/4G, OR = 0.841, 95% CI = 0.415-1.704, P = 0.631). CONCLUSIONS: There is no statistically significant association between the 4G/5G polymorphism of PAI-1 gene and SSNHL in the Caucasian population, and well-designed studies covering more patients and institutions should be conducted.
Authors: P Capaccio; F Ottaviani; V Cuccarini; U Ambrosetti; E Fagnani; A Bottero; S Cenzuales; B M Cesana; L Pignataro Journal: Genet Med Date: 2005-03 Impact factor: 8.822
Authors: Robert J Stachler; Sujana S Chandrasekhar; Sanford M Archer; Richard M Rosenfeld; Seth R Schwartz; David M Barrs; Steven R Brown; Terry D Fife; Peg Ford; Theodore G Ganiats; Deena B Hollingsworth; Christopher A Lewandowski; Joseph J Montano; James E Saunders; Debara L Tucci; Michael Valente; Barbara E Warren; Kathleen L Yaremchuk; Peter J Robertson Journal: Otolaryngol Head Neck Surg Date: 2012-03 Impact factor: 3.497
Authors: R Marcucci; A Alessandrello Liotta; A P Cellai; A Rogolino; P Berloco; E Leprini; P Pagnini; R Abbate; D Prisco Journal: J Thromb Haemost Date: 2005-05 Impact factor: 5.824