| Literature DB >> 32900951 |
Bruna B Brandão1,2,3, Søren Madsen4, Atefeh Rabiee4, Matteo Oliverio5,6,7, Gabriel P Ruiz8,9, Danilo L Ferrucci9, Jéssica L Branquinho1,2, Daniela Razolli10,11, Silas Pinto8,9, Thomas S Nielsen4, William T Festuccia12, Adriano S Martins1,2,13, Beatriz A Guerra1,2,9, Thiago L Knittel8,9, Ditte Søgaard14, Steen Larsen14,15, Jørn W Helge14, Josef Brandauer16, Lício A Velloso10, Brice Emanuelli4, Jan-Wilhelm Kornfeld17, C Ronald Kahn18, Sara G Vienberg4, Juleen R Zierath4,19, Jonas T Treebak20, Marcelo A Mori21,2,8,9,10,22.
Abstract
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.Entities:
Keywords: adipose tissue; cross-talk; exercise; metabolic flexibility; microRNA
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Year: 2020 PMID： 32900951 PMCID： PMC7519274 DOI： 10.1073/pnas.2011243117
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205