Olivia Sgarbura1, Laurent Villeneuve2, Mohammad Alyami3, Naoual Bakrin4, Juan José Torrent5, Clarisse Eveno6, Martin Hübner7. 1. Department of Surgical Oncology, Montpellier Cancer Institute, University of Montpellier, France. Electronic address: Olivia.sgarbura@icm.unicancer.fr. 2. Department of Clinical and Epidemiological Research, Department of Public Health, Lyon Sud University Hospital, EA, 3738, Lyon 1 University, Lyon, France. 3. Department of Surgery, Oncology center, King Khalid hospital, Najran, Saudi Arabia. 4. Department of Digestive Surgery, Lyon Sud University Hospital, EA, 3738, Lyon 1 University, Lyon, France. 5. Department of Surgical Oncology, Torrent Quénet Institute, Barcelona, Spain. 6. Department of Digestive and Oncologic Surgery, Claude Huriez University Hospital, Centre Hospitalier Universitaire (CHU), Lille. 7. Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Switzerland.
Abstract
BACKGROUND: PIPAC is a new treatment modality for peritoneal cancer which has been practiced and evaluated until very recently by few academic centers in a highly standardized manner. Encouraging oncological outcomes and the safety profile have led to widespread adoption. The aim of this study was to assess current PIPAC practice in terms of technique, treatment and safety protocol, and indications. METHODS: A standardized survey with 82 closed-ended questions was sent online to active PIPAC centers which were identified by help of PIPAC training centers and the regional distributors of the PIPAC-specific nebulizer. The survey inquired about center demographics (n = 8), technique (n = 34), treatment and safety protocol (n = 34), and indications (n = 6). RESULTS: Overall, 62 out of 66 contacted PIPAC centers answered the survey (response rate 93%). 27 centers had performed >60 PIPAC procedures. A consensus higher than 70% was reached for 37 items (50%), and higher than 80% for 28 items (37.8%). The topics with the highest degree of consensus were safety and installation issues (93.5% and 80.65%) while chemotherapy and response evaluation were the least consensual topics (63.7 and 59.6%). The attitudes were not influenced by volume, PIPAC starting year, type of activity, or presence of peritoneal metastases program. CONCLUSION: Homogeneous treatment standards of new techniques are important to guarantee safe implementation and practice but also to allow comparison between cohorts and multi-center analysis of merged data including registries. Efforts to avoid diversification of PIPAC practice include regular update of the PIPAC training curriculum, targeted research and a consensus statement.
BACKGROUND:PIPAC is a new treatment modality for peritoneal cancer which has been practiced and evaluated until very recently by few academic centers in a highly standardized manner. Encouraging oncological outcomes and the safety profile have led to widespread adoption. The aim of this study was to assess current PIPAC practice in terms of technique, treatment and safety protocol, and indications. METHODS: A standardized survey with 82 closed-ended questions was sent online to active PIPAC centers which were identified by help of PIPAC training centers and the regional distributors of the PIPAC-specific nebulizer. The survey inquired about center demographics (n = 8), technique (n = 34), treatment and safety protocol (n = 34), and indications (n = 6). RESULTS: Overall, 62 out of 66 contacted PIPAC centers answered the survey (response rate 93%). 27 centers had performed >60 PIPAC procedures. A consensus higher than 70% was reached for 37 items (50%), and higher than 80% for 28 items (37.8%). The topics with the highest degree of consensus were safety and installation issues (93.5% and 80.65%) while chemotherapy and response evaluation were the least consensual topics (63.7 and 59.6%). The attitudes were not influenced by volume, PIPAC starting year, type of activity, or presence of peritoneal metastases program. CONCLUSION: Homogeneous treatment standards of new techniques are important to guarantee safe implementation and practice but also to allow comparison between cohorts and multi-center analysis of merged data including registries. Efforts to avoid diversification of PIPAC practice include regular update of the PIPAC training curriculum, targeted research and a consensus statement.
Authors: Stefano Rotolo; Andrea Di Giorgio; Marco Cintoni; Emanuele Rinninella; Marta Palombaro; Gabriele Pulcini; Carlo Alberto Schena; Vito Chiantera; Giuseppe Vizzielli; Antonio Gasbarrini; Fabio Pacelli; Maria Cristina Mele Journal: Pleura Peritoneum Date: 2022-03-01
Authors: Olivia Sgarbura; Clarisse Eveno; Mohammad Alyami; Naoual Bakrin; Delia Cortes Guiral; Wim Ceelen; Xavier Delgadillo; Thanh Dellinger; Andrea Di Giorgio; Amaniel Kefleyesus; Vladimir Khomiakov; Michael Bau Mortensen; Jamie Murphy; Marc Pocard; Marc Reymond; Manuela Robella; Koen P Rovers; Jimmy So; S P Somashekhar; Clemens Tempfer; Kurt Van der Speeten; Laurent Villeneuve; Wei Peng Yong; Martin Hübner Journal: Pleura Peritoneum Date: 2022-03-01
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Authors: Robin J Lurvink; Paulien Rauwerdink; Koen P Rovers; Emma C E Wassenaar; Maarten J Deenen; Joost Nederend; Clément J R Huysentruyt; Iris van 't Erve; Remond J A Fijneman; Erik J R J van der Hoeven; Cornelis A Seldenrijk; Alexander Constantinides; Onno Kranenburg; Maartje Los; Karin H Herbschleb; Anna M J Thijs; Geert-Jan M Creemers; Jacobus W A Burger; Marinus J Wiezer; Simon W Nienhuijs; Djamila Boerma; Ignace H J T de Hingh Journal: BMJ Open Date: 2021-03-30 Impact factor: 2.692
Authors: Laura Toussaint; Hugo Teixeira Farinha; Jean-Luc Barras; Nicolas Demartines; Christine Sempoux; Martin Hübner Journal: Pleura Peritoneum Date: 2021-07-15
Authors: Robin J Lurvink; Koen P Rovers; Emma C E Wassenaar; Checca Bakkers; Jacobus W A Burger; Geert-Jan M Creemers; Maartje Los; Floortje Mols; Marinus J Wiezer; Simon W Nienhuijs; Djamila Boerma; Ignace H J T de Hingh Journal: Surg Endosc Date: 2021-11-10 Impact factor: 3.453
Authors: Mojib Fallah; Sönke Detlefsen; Alan P Ainsworth; Claus W Fristrup; Michael B Mortensen; Per Pfeiffer; Line S Tarpgaard; Martin Graversen Journal: Pleura Peritoneum Date: 2022-05-30