Literature DB >> 32898687

The emergence of hypervirulent blaNDM-1-positive Klebsiella pneumoniae sequence type 395 in an oncology hospital.

Irina Lazareva1, Vladimir Ageevets1, Julia Sopova2, Marina Lebedeva3, Polina Starkova4, Daria Likholetova5, Maria Lebedeva6, Vladimir Gostev7, Vladimir Moiseenko3, Vitaliy Egorenkov3, Arina Navatskaya3, Galina Mitroshina3, Elena Myasnikova8, Irina Tsvetkova1, Yuri Lobzin7, Sergey Sidorenko9.   

Abstract

Fifteen hypermucoviscous isolates (13 blaNDM-1-positive) obtained from 11 oncology patients were analyzed by whole genome sequencing, and selected isolates were assessed in a murine model of sepsis. ST395/K2 isolates harboring rmpA, rmpA2, peg-344, aerobactin, enterobactin, yersiniabactin, type I fimbriae, etc. displayed maximal virulence in the mouse lethality assay (LD50 = 102 CFU). ST147/K20 isolates lacking yersiniabactins were relatively less virulent (LD50 = 104 CFU), ST395/K2 isolates lacking rmpA, rmpA2, peg-344, and aerobactin, but harboring yersiniabactin demonstrated minimal virulence (LD50 = 105 CFU). Isolates represent various paths and stages of evolution directed towards convergence of multidrugresistant classical Klebsiella pneumoniae and hypervirulent K. pneumoniae.
Copyright © 2020 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Antimicrobial resistance; Hypermucoviscous Klebsiella pneumoniae; New Delhi metallo-beta-lactamase 1; Virulence

Year:  2020        PMID： 32898687     DOI： 10.1016/j.meegid.2020.104527

Source DB:  PubMed          Journal:  Infect Genet Evol        ISSN： 1567-1348            Impact factor:   3.342


  5 in total

1.  Unusual Hypermucoviscous Clinical Isolate of Klebsiella pneumoniae with No Known Determinants of Hypermucoviscosity.

Authors:  Tamal Dey; Ardhendu Chakrabortty; Aastha Kapoor; Anuja Warrier; Vijaya Lakshmi Nag; Karthikeyan Sivashanmugam; Manoharan Shankar
Journal:  Microbiol Spectr       Date:  2022-06-01

2.  Molecular Epidemiology of Hypervirulent K. pneumoniae and Problems of Health-Care Associated Infections.

Authors:  A V Tutelyan; D S Shlykova; Sh L Voskanyan; A M Gaponov; V M Pisarev
Journal:  Bull Exp Biol Med       Date:  2022-03-30       Impact factor: 0.737

Review 3.  Finding Order in the Chaos: Outstanding Questions in Klebsiella pneumoniae Pathogenesis.

Authors:  Shekina Gonzalez-Ferrer; Hernán F Peñaloza; James A Budnick; William G Bain; Hayley R Nordstrom; Janet S Lee; Daria Van Tyne
Journal:  Infect Immun       Date:  2021-03-17       Impact factor: 3.441

4.  Early Response of Antimicrobial Resistance and Virulence Genes Expression in Classical, Hypervirulent, and Hybrid hvKp-MDR Klebsiella pneumoniae on Antimicrobial Stress.

Authors:  Anastasiia D Fursova; Mikhail V Fursov; Evgenii I Astashkin; Tatiana S Novikova; Galina N Fedyukina; Angelina A Kislichkina; Irina A Alexandrova; Olga N Ershova; Ivan A Dyatlov; Nadezhda K Fursova
Journal:  Antibiotics (Basel)       Date:  2021-12-22

5.  An Assessment of Siderophore Production, Mucoviscosity, and Mouse Infection Models for Defining the Virulence Spectrum of Hypervirulent Klebsiella pneumoniae.

Authors:  Thomas A Russo; Ulrike MacDonald; Sidra Hassan; Ellie Camanzo; Francois LeBreton; Brendan Corey; Patrick McGann
Journal:  mSphere       Date:  2021-03-24       Impact factor: 4.389
  5 in total

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