Literature DB >> 3289795

Glutamate dehydrogenase: biochemical and clinical aspects of an interesting enzyme.

E S Schmidt1, F W Schmidt.   

Abstract

The molecular properties and possible metabolic functions of glutamate dehydrogenase (GLDH-EC 1.4.1.3) are described. The distribution of this enzyme in the body and particularly in the liver are outlined. The significance of these properties for GLDH release into the extracellular space, for the distribution and elimination of the enzyme and, foremost, for the assay of GLDH as a diagnostic indicator of hepatic and biliary disease are shown. Analytical methods are reviewed.

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Year:  1988        PMID： 3289795     DOI： 10.1016/0009-8981(88)90356-7

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  13 in total

1.  An enzymatic bridge between carbohydrate and amino acid metabolism: regulation of glutamate dehydrogenase by reversible phosphorylation in a severe hypoxia-tolerant crayfish.

Authors:  Neal J Dawson; Kenneth B Storey
Journal:  J Comp Physiol B       Date:  2011-11-11       Impact factor: 2.200

2.  Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.

Authors:  Rachel J Church; Gerd A Kullak-Ublick; Jiri Aubrecht; Herbert L Bonkovsky; Naga Chalasani; Robert J Fontana; Jens C Goepfert; Frances Hackman; Nicholas M P King; Simon Kirby; Patrick Kirby; John Marcinak; Sif Ormarsdottir; Shelli J Schomaker; Ina Schuppe-Koistinen; Francis Wolenski; Nadir Arber; Michael Merz; John-Michael Sauer; Raul J Andrade; Florian van Bömmel; Thierry Poynard; Paul B Watkins
Journal:  Hepatology       Date:  2018-06-27       Impact factor: 17.425

Review 3.  The transformation in biomarker detection and management of drug-induced liver injury.

Authors:  Rachel J Church; Paul B Watkins
Journal:  Liver Int       Date:  2017-05-08       Impact factor: 5.828

Review 4.  Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation.

Authors:  Mitchell R McGill; Hartmut Jaeschke
Journal:  Expert Rev Mol Diagn       Date:  2018-08-13       Impact factor: 5.225

5.  Effects of atherogenic diet on hepatic gene expression across mouse strains.

Authors:  Keith R Shockley; David Witmer; Sarah L Burgess-Herbert; Beverly Paigen; Gary A Churchill
Journal:  Physiol Genomics       Date:  2009-08-11       Impact factor: 3.107

6.  Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals.

Authors:  Aleksey Yevtodiyenko; Arkadiy Bazhin; Pavlo Khodakivskyi; Aurelien Godinat; Ghyslain Budin; Tamara Maric; Giorgio Pietramaggiori; Sandra S Scherer; Marina Kunchulia; George Eppeldauer; Sergey V Polyakov; Kevin P Francis; Jeffrey N Bryan; Elena A Goun
Journal:  Nat Commun       Date:  2021-05-11       Impact factor: 14.919

7.  The effects of heparins on the liver: application of mechanistic serum biomarkers in a randomized study in healthy volunteers.

Authors:  A H Harrill; J Roach; I Fier; J S Eaddy; C L Kurtz; D J Antoine; D M Spencer; T K Kishimoto; D S Pisetsky; B K Park; P B Watkins
Journal:  Clin Pharmacol Ther       Date:  2012-06-27       Impact factor: 6.875

8.  Impact of body weight gain on hepatic metabolism and hepatic inflammatory cytokines in comparison of Shetland pony geldings and Warmblood horse geldings.

Authors:  Carola Schedlbauer; Dominique Blaue; Martin Gericke; Matthias Blüher; Janine Starzonek; Claudia Gittel; Walter Brehm; Ingrid Vervuert
Journal:  PeerJ       Date:  2019-06-07       Impact factor: 2.984

9.  Vitamin E-Induced Changes in Glutamate and GABA Metabolizing Enzymes of Chick Embryo Cerebrum.

Authors:  Ivy Pereira; Shanti N Dessai; Annaliza Pinto
Journal:  ISRN Neurol       Date:  2013-07-29

10.  Benign elevations in serum aminotransferases and biomarkers of hepatotoxicity in healthy volunteers treated with cholestyramine.

Authors:  Rohit Singhal; Alison H Harrill; Francoise Menguy-Vacheron; Zaid Jayyosi; Hadj Benzerdjeb; Paul B Watkins
Journal:  BMC Pharmacol Toxicol       Date:  2014-08-03       Impact factor: 2.483
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