Intrinsic control of the gut.

In most mammals (except ruminants) activity in the gastrointestinal (GI) tract depends upon the condition or state of the animal, namely, fasted or fed. The fasted state is characterized by a caudally migrating, cycling motor complex, showing periods of intense contractile and secretory activity alternating with periods of quiescence. Although the mechanisms involved in the transition from the fasted to the fed state are not fully understood it seems likely that both states utilize intrinsically located neural control mechanisms and common neuronal pathways to the effector tissues. We have commented on the reported properties of the myenteric neurones and their projections to the muscle layers. The data suggests that there are both cholinergic and non-cholinergic excitatory motor neurones supplying the muscle layers. In the guinea-pig, at least, the projections of the neurones to the circular muscle layer run for relatively short distances in oral-aboral axis of the gut. The non-cholinergic excitatory transmitter substance may be Substance P or a similar tachykinin. Other excitatory nerves may well be present. There are at least two mechanisms used by non-cholinergic non-adrenergic inhibitory nerves supplying the muscle layers. In the guinea-pig ileum, there are at least two distinct projections of inhibitory motor neurones; both have aborally directed projections. The first of these is relatively short and the other long (greater than 10 mm). Individual myenteric neurones appear to contain unique and perhaps identifying groups of peptides. The functional role of many of these peptides, either within the myenteric plexus or their projections to the muscle layers, remains to be elucidated. The projections of the neurones of the submucous plexus run primarily to the mucosa. Both cholinergic and non-cholinergic secretomotor neurones appear to be present. The activation of local neural reflexes, which results in secretomotor activity, may involve submucous sensory neurones containing acetylcholine and Substance P together with cholinergic interneurones. Projections from the myenteric to the submucous plexus are likely to be involved in the coordination of intestinal movement and secretomotor activity. A simplified schematic diagram of some of the neuronal circuitry of the submucous plexus has been developed and includes the findings from immunocytochemical and electrophysiological studies.