Ying Liu1, Yu Zhang2, Yan Tian2. 1. Department of Gynecology, Zhuzhou Kind Cardiovascular Disease Hospital, Zhuzhou 412000, China. 2. Department of Gynecology and Obstetrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Abstract
OBJECTIVE: To observe the expression of HELQ and RAD51C in normal endometrial and endometrial stromal sarcoma (ESS) and analyze their correlation with the clinical features of the patients. METHODS: The expressions of HELQ and RAD51C proteins were detected by immunohistochemical staining in normal endometrial tissues (14 cases) and tumor tissues from patients with ESS (37 cases) treated in Hunan Provincial Cancer Hospital from January, 2013 to December, 2016. The correlations of the expressions of the two proteins with the patients'age, FIGO staging, tissue type, tumor size, and lymph node metastasis were analyzed. RESULTS: Immunohistochemical staining showed that the expressions of HELQ and RAD51C were both decreased in ESS patients compared with the normal group, and there was a positive correlation between HELQ and RAD51C expression (P < 0.05). HELQ expression in ESS was correlated with the tumor size and type. The expressions of HELQ and RAD51C were not correlated with the patients' age, FIGO stage and status of lymph node metastasis (P > 0.05). CONCLUSIONS: Homologous recombination- directed DNA repair involving HELQ and RAD51C may participate in the occurrence and progression of ESS.
OBJECTIVE: To observe the expression of HELQ and RAD51C in normal endometrial and endometrial stromal sarcoma (ESS) and analyze their correlation with the clinical features of the patients. METHODS: The expressions of HELQ and RAD51C proteins were detected by immunohistochemical staining in normal endometrial tissues (14 cases) and tumor tissues from patients with ESS (37 cases) treated in Hunan Provincial Cancer Hospital from January, 2013 to December, 2016. The correlations of the expressions of the two proteins with the patients'age, FIGO staging, tissue type, tumor size, and lymph node metastasis were analyzed. RESULTS: Immunohistochemical staining showed that the expressions of HELQ and RAD51C were both decreased in ESS patients compared with the normal group, and there was a positive correlation between HELQ and RAD51C expression (P < 0.05). HELQ expression in ESS was correlated with the tumor size and type. The expressions of HELQ and RAD51C were not correlated with the patients' age, FIGO stage and status of lymph node metastasis (P > 0.05). CONCLUSIONS: Homologous recombination- directed DNA repair involving HELQ and RAD51C may participate in the occurrence and progression of ESS.
Entities:
Keywords:
DNA damage repair; HELQ; RAD51C; endometrial stromal sarcoma
Authors: Andrew P Sciallis; Patrick P Bedroske; John K Schoolmeester; William R Sukov; Gary L Keeney; Jennelle C Hodge; Debra A Bell Journal: Am J Surg Pathol Date: 2014-09 Impact factor: 6.394
Authors: Evgenia V Dolgova; Ekaterina A Alyamkina; Yaroslav R Efremov; Valeriy P Nikolin; Nelly A Popova; Tamara V Tyrinova; Artem V Kozel; Alexandra M Minkevich; Oleg M Andrushkevich; Evgeniy L Zavyalov; Alexander V Romaschenko; Sergey I Bayborodin; Oleg S Taranov; Vladimir V Omigov; Ekaterina Ya Shevela; Vyacheslav V Stupak; Sergey V Mishinov; Vladimir A Rogachev; Anastasia S Proskurina; Vladimir I Mayorov; Mikhail A Shurdov; Alexander A Ostanin; Elena R Chernykh; Sergey S Bogachev Journal: Cancer Biol Ther Date: 2014-10 Impact factor: 4.742