Literature DB >> 32895124

[Prevention and control of SARS-CoV-2 infection in clinical laboratories: implementation of contingency plan and postpandemic response strategies].

Jianfeng Hang1, Zhaohui Sun1, Linhai Li1.   

Abstract

The outbreak of COVID-19 has currently been under control in China, but now the disease has rapidly evolved into a global pandemic. We formulated a prevention and control plan for clinical laboratories responsible for detection of the novel coronavirus infection. We analyzed the implementation of this plan and the problems arising from its clinical practice. We found that the layout of most clinical laboratories (including gene amplification laboratories for clinical samples) was inadequate in response to a major outbreak and did not meet the requirements for biosafety protection and etiology and serology testing; and laboratory staff showed insufficiencies in their awareness regarding biosafety protection; the functions and status of the laboratory in the fever clinic need to be enhanced to increase its detection capacity; the high density of military personnel, the low level of automation of clinical laboratory equipment, and the lack of biosafety cabinets and personal protective equipment all limit the performance of diverse military operations and major overseas missions. In view of these problems, we propose the following strategies and recommendations: the clinical laboratory needs to standardize the design and staff management according to the standards of P2 laboratory; the detection capacity and staffing of fever clinic laboratory in hospitals need to be strengthened, and a separate clinical gene amplification laboratory can be optimal; for those clinical gene amplification laboratories that fail to meet these standards, reconstruction and upgrade should be made according to the requirements of biosafety protection; for the clinical laboratory in the military medical system, in addition to enforcement of biological safety protection of the staff, sufficient supply of medical materials and biological safety equipment should be ensured and biological safety cabinets should be routinely equipped if possible.

Entities:  

Keywords:  MERS; SARS; SARS-CoV-2; biosafety; nucleic acid

Mesh:

Year:  2020        PMID: 32895124      PMCID: PMC7225104          DOI: 10.12122/j.issn.1673-4254.2020.04.25

Source DB:  PubMed          Journal:  Nan Fang Yi Ke Da Xue Xue Bao        ISSN: 1673-4254


  6 in total

1.  A major outbreak of severe acute respiratory syndrome in Hong Kong.

Authors:  Nelson Lee; David Hui; Alan Wu; Paul Chan; Peter Cameron; Gavin M Joynt; Anil Ahuja; Man Yee Yung; C B Leung; K F To; S F Lui; C C Szeto; Sydney Chung; Joseph J Y Sung
Journal:  N Engl J Med       Date:  2003-04-07       Impact factor: 91.245

Review 2.  Middle East respiratory syndrome coronavirus (MERS-CoV): A review.

Authors:  Nour Ramadan; Houssam Shaib
Journal:  Germs       Date:  2019-03-01

Review 3.  Severe acute respiratory syndrome: review and lessons of the 2003 outbreak.

Authors:  Umesh D Parashar; Larry J Anderson
Journal:  Int J Epidemiol       Date:  2004-05-20       Impact factor: 7.196

4.  What to do next to control the 2019-nCoV epidemic?

Authors:  Fu-Sheng Wang; Chao Zhang
Journal:  Lancet       Date:  2020-02-08       Impact factor: 79.321

5.  Three Emerging Coronaviruses in Two Decades.

Authors:  Jeannette Guarner
Journal:  Am J Clin Pathol       Date:  2020-03-09       Impact factor: 2.493

6.  A new coronavirus associated with human respiratory disease in China.

Authors:  Fan Wu; Su Zhao; Bin Yu; Yan-Mei Chen; Wen Wang; Zhi-Gang Song; Yi Hu; Zhao-Wu Tao; Jun-Hua Tian; Yuan-Yuan Pei; Ming-Li Yuan; Yu-Ling Zhang; Fa-Hui Dai; Yi Liu; Qi-Min Wang; Jiao-Jiao Zheng; Lin Xu; Edward C Holmes; Yong-Zhen Zhang
Journal:  Nature       Date:  2020-02-03       Impact factor: 49.962

  6 in total
  1 in total

1.  Increased Adherence to Infection Control Practices Among Medical Laboratory Technicians During the COVID-19 Pandemic: A Self-Reported Survey Study.

Authors:  Refat Nimer; Samer Swedan; Hassan Kofahi; Omar Khabour
Journal:  Ann Glob Health       Date:  2021-06-25       Impact factor: 2.462

  1 in total

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