Paulina Maria Przybycien-Gaweda1, Xinyi Gwee1, Qi Gao1, Denise Qian Ling Chua1, Johnson Fam1, Tze Pin Ng2. 1. Department of Psychological Medicine, Gerontology Research Programme, National University of Singapore, Singapore, Singapore. 2. Department of Psychological Medicine, Gerontology Research Programme, National University of Singapore, Singapore, Singapore, pcmngtp@nus.edu.sg.
Abstract
BACKGROUND/AIM: Studies of the associations of the metabolic syndrome (MetS) with cognitive function and decline are inconclusive. We investigated the associations of the MetS with cognitive functions in 823 Chinese >55-year-olds followed up over 4.5 years. METHODS: The relationships between the MetS and baseline and follow-up z-scores of cognitive domain functions were examined using mixed model analysis. RESULTS: There were specific inverse cross-sectional associations of single cardiometabolic risk factors with cognition, such as hyperglycemia with processing speed (p = 0.045). The MetS was negatively associated with 3 out of 4 cognitive domains (p = 0.018 to p = 0.003), and the count of cardiometabolic risk factors with all cognitive domains (p = 0.025 to p = 0.002). Longitudinally, dyslipidemia was associated with worse decline in memory and learning (p = 0.022). The count of cardiometabolic risk factors was associated with worse declines in cognition (p = 0.032 for global cognition). CONCLUSION: Among middle-aged and older Asians, an increased number of component cardiometabolic risk factors of the MetS was associated with a worse decline in cognitive function over time.
BACKGROUND/AIM: Studies of the associations of the metabolic syndrome (MetS) with cognitive function and decline are inconclusive. We investigated the associations of the MetS with cognitive functions in 823 Chinese >55-year-olds followed up over 4.5 years. METHODS: The relationships between the MetS and baseline and follow-up z-scores of cognitive domain functions were examined using mixed model analysis. RESULTS: There were specific inverse cross-sectional associations of single cardiometabolic risk factors with cognition, such as hyperglycemia with processing speed (p = 0.045). The MetS was negatively associated with 3 out of 4 cognitive domains (p = 0.018 to p = 0.003), and the count of cardiometabolic risk factors with all cognitive domains (p = 0.025 to p = 0.002). Longitudinally, dyslipidemia was associated with worse decline in memory and learning (p = 0.022). The count of cardiometabolic risk factors was associated with worse declines in cognition (p = 0.032 for global cognition). CONCLUSION: Among middle-aged and older Asians, an increased number of component cardiometabolic risk factors of the MetS was associated with a worse decline in cognitive function over time.
Authors: Sarah Gauci; Lauren M Young; Lizanne Arnoldy; Andrew Scholey; David J White; Annie-Claude Lassemillante; Denny Meyer; Andrew Pipingas Journal: Front Nutr Date: 2022-04-28
Authors: Olga Lucia Pedraza; Isis Camacho; Fabio Alexander Sierra; Rubio-Gómez Cladelis; Ana Maria Salazar; Maria Camila Montalvo; Hector Daniel Morillo; Angela Lozano; Luz Dary Gutiérrez-Castañeda; Lilian Torres-Tobar; Cesar Piñeros Journal: Dement Neuropsychol Date: 2021 Oct-Dec