Literature DB >> 3289118

Astrocyte mitogen inhibitor related to epidermal growth factor receptor.

M Nieto-Sampedro1.   

Abstract

Epidermal growth factor (EGF) is a well-characterized polypeptide hormone with diverse biological activities, including stimulation of astrocyte division. A soluble astrocyte mitogen inhibitor, immunologically related to the EGF receptor, is present in rat brain. Injury to the brain causes a time-dependent reduction in the levels of this inhibitor and the concomitant appearance of EGF receptor on the astrocyte surface. Intracerebral injection of antibody capable of binding the inhibitor caused the appearance of numerous reactive astrocytes. EGF receptor-related inhibitors may play a key role in the control of glial cell division in both normal and injured brain.

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Year:  1988        PMID： 3289118     DOI： 10.1126/science.3289118

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

Review 1.  Roles of transforming growth factor-alpha and related molecules in the nervous system.

Authors:  C J Xian; X F Zhou
Journal:  Mol Neurobiol       Date:  1999 Oct-Dec       Impact factor: 5.590

2.  Beneficial effects of x-irradiation on recovery of lesioned mammalian central nervous tissue.

Authors:  N Kalderon; A A Alfieri; Z Fuks
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

3.  Serum and transforming growth factor beta regulate glial fibrillary acidic protein in serum-free-derived mouse embryo cells.

Authors:  Y Sakai; C Rawson; K Lindburg; D Barnes
Journal:  Proc Natl Acad Sci U S A       Date:  1990-11       Impact factor: 11.205

4.  Glioma growth inhibition by neurostatin and O-But GD1b.

Authors:  Beatriz Valle-Argos; Diego Gómez-Nicola; Manuel Nieto-Sampedro
Journal:  Neuro Oncol       Date:  2010-07-08       Impact factor: 12.300

5.  Inhibitors of Glioma Growth that Reveal the Tumour to the Immune System.

Authors:  Manuel Nieto-Sampedro; Beatriz Valle-Argos; Diego Gómez-Nicola; Alfonso Fernández-Mayoralas; Manuel Nieto-Díaz
Journal:  Clin Med Insights Oncol       Date:  2011-09-21

6.  A truncated, secreted form of the epidermal growth factor receptor is encoded by an alternatively spliced transcript in normal rat tissue.

Authors:  L A Petch; J Harris; V W Raymond; A Blasband; D C Lee; H S Earp
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

7.  Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs).

Authors:  E M Hiesiger; R L Hayes; D M Pierz; G N Budzilovich
Journal:  J Neurooncol       Date:  1993-05       Impact factor: 4.130

8.  Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor.

Authors:  R M Hu; E R Levin
Journal:  J Clin Invest       Date:  1994-04       Impact factor: 14.808

Review 9.  Posttraumatic epilepsy: hemorrhage, free radicals and the molecular regulation of glutamate.

Authors:  L J Willmore; Yuto Ueda
Journal:  Neurochem Res       Date:  2008-09-11       Impact factor: 3.996

10.  p-Chlorophenylalanine, a serotonin synthesis inhibitor, reduces the response of glial fibrillary acidic protein induced by trauma to the spinal cord. An immunohistochemical investigation in the rat.

Authors:  H S Sharma; Y Olsson; J Cervós-Navarro
Journal:  Acta Neuropathol       Date:  1993       Impact factor: 17.088
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