Editorial: The Preschool Emotional Brain.

There is broad consensus that children's ability to regulate emotion, particularly negative affect, can have enormous implications for the cascading processes underlying social and emotional development. With the burgeoning autonomy of toddlerhood comes a rudimentary understanding of the varieties of emotional experience, and initial awareness that a child's actions can augment or attenuate the intensity of those experiences. Successful forays into emotion regulation are crucial for healthy psychological development, allowing children to accommodate life's difficulties by purposefully altering their emotional state (ie, coping) when necessary. By contrast, persistent negative affect in childhood is known to increase the risk for depression by late adolescence.1 Neuroimaging studies in youth and adults have implicated a key circuit in the generation and regulation of negative affect including the amygdala, a subcortical structure that detects emotionally salient information, and the medial prefrontal cortex (mPFC), a cortical region known to exert regulatory influence on the amygdala. Synchronous activation of these regions, reflecting functional transmission of information between them, is conceptually and empirically linked to individual differences in the intensity and purposeful modulation of emotion.2 Furthermore, amygdala reactivity is associated with negative affect in preschoolers,3 whereas emotion-related amygdala-mPFC connectivity may shape the subsequent development of resting (intrinsic) amygdala-mPFC connectivity, particularly in childhood.4.