Diego F Salazar-Tortosa1,2,3, Jose M Pascual-Gamarra1,4, Idoia Labayen5, Azahara I Rupérez6,7,8, Laura Censi9, Laurent Béghin10, Nathalie Michels11, Marcela González-Gross12, Yannis Manios13, Christina-Paulina Lambrinou13, Luis A Moreno6,7,8,14,15, Aline Meirhaeghe16, Manuel J Castillo4, Jonatan R Ruiz1,17,18. 1. PROFITH 'PROmoting FITness and Health through physical activity' research group, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. 2. Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA. 3. Department of Ecology, Faculty of Sciences. 4. Department of Medical Physiology, Faculty of Medicine, University of Granada, Granada. 5. Institute for Innovation & Sustainable Development in Food Chain (IS-FOOD), Department of Health Sciences, Navarra's Health Research Institute (IdiSNA), Public University of Navarra, Pamplona. 6. Growth, Exercise, Nutrition and Development (GENUD) Research Group, University of Zaragoza. 7. Instituto Agroalimentario de Aragón (IA2). 8. Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain. 9. Council for Agricultural Research and Economics (CREA), Research Centre for Food and Nutrition, Rome, Italy. 10. Univ. Lille, Inserm, CHU Lille, CIC 1403 - Clinique Investigation Center and U1286 - INFINITE - Institute for Translational Research in Inflammation, F-59000 Lille, France. 11. Department of Public Health and Primary Care, Ghent University, Belgium. 12. Department of Health and Human Performance, Universidad Politécnica de Madrid, Madrid, Spain. 13. Department of Nutrition and Dietetics, Harokopio University of Athens, Greece. 14. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III, Madrid. 15. Faculty of Health Sciences, University of Zaragoza, Zaragoza, Spain. 16. Inserm, Institut Pasteur de Lille, University Lille, UMR1167-RID-AGE-Risk factors and molecular determinants of aging-related diseases, Lille, France. 17. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. 18. Department of Biosciences and Nutrition at NOVUM, Karolinska Institutet, Huddinge, Sweden.
Abstract
OBJECTIVES: Cardiovascular diseases (CVDs) are responsible of 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. Aims of present research are to examine the association of ADIPOQ gene polymorphisms with cardiovascular disease risk factors in European adolescents. METHODS: A total of 14 polymorphisms in the ADIPOQ gene were genotyped in 1057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. We measured serum lipids and a CVD risk score, along with weight, height, triceps, and subscapular skinfold thickness, leptin, insulin and other markers of glucose regulation. RESULTS: The rs822393, rs822395 and rs7649121 polymorphisms of ADIPOQ gene were significantly associated with several CVD risk factors [i.e. high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1, SBP and CVD risk score] in European adolescents. We also found an association of the TGAAGT ADIPOQ haplotype (rs822393, rs16861210, rs822395, rs822396, rs12495941 and rs7649121) with HDL-C and ApoA1 levels. CONCLUSION: Several individual polymorphisms (rs822393, rs822395 and rs7649121) and a haplotype of ADIPOQ gene were significantly associated with cardiovascular disease risk factors in European adolescents.
OBJECTIVES:Cardiovascular diseases (CVDs) are responsible of 31% of all deaths worldwide. Genetic predisposition to CVDs in adolescents remains largely unknown. Aims of present research are to examine the association of ADIPOQ gene polymorphisms with cardiovascular disease risk factors in European adolescents. METHODS: A total of 14 polymorphisms in the ADIPOQ gene were genotyped in 1057 European adolescents (12-18 years old) from the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study. We measured serum lipids and a CVD risk score, along with weight, height, triceps, and subscapular skinfold thickness, leptin, insulin and other markers of glucose regulation. RESULTS: The rs822393, rs822395 and rs7649121 polymorphisms of ADIPOQ gene were significantly associated with several CVD risk factors [i.e. high-density lipoprotein cholesterol (HDL-C), apolipoprotein (Apo) A1, SBP and CVD risk score] in European adolescents. We also found an association of the TGAAGT ADIPOQ haplotype (rs822393, rs16861210, rs822395, rs822396, rs12495941 and rs7649121) with HDL-C and ApoA1 levels. CONCLUSION: Several individual polymorphisms (rs822393, rs822395 and rs7649121) and a haplotype of ADIPOQ gene were significantly associated with cardiovascular disease risk factors in European adolescents.