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Literature DB >> 3288996

Immunological identification of a high molecular weight protein as a candidate for the product of the Duchenne muscular dystrophy gene.

L Kao¹, J Krstenansky, J Mendell, K W Rammohan, E Gruenstein.

Abstract

An oligopeptide was synthesized based on translation of the nucleotide sequence of the putative exon region of clone pERT87-25 from the gene for Duchenne muscular dystrophy. Immunization of rabbits with this oligopeptide induced the formation of antibodies directed against a protein present in human, rat, and rabbit skeletal muscle. This protein, which is missing in the skeletal muscle of two patients with Duchenne muscular dystrophy, has a molecular mass of approximately equal to 320-420 kDa and is clearly different from the putative Duchenne muscular dystrophy-related protein nebulin. The data suggest that this 320- to 420-kDa protein is produced by the Duchenne muscular dystrophy gene.

Entities: Disease Species

Mesh：

Substances：

Year: 1988 PMID： 3288996 PMCID： PMC280456 DOI： 10.1073/pnas.85.12.4491

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

13 in total

1. Subcellular fractionation of dystrophin to the triads of skeletal muscle.

Authors: E P Hoffman; C M Knudson; K P Campbell; L M Kunkel
Journal: Nature Date: 1987 Dec 24-31 Impact factor: 49.962

2. Natural autoantibodies constitute a substantial part of normal circulating immunoglobulins.

Authors: G Dighiero; P Lymberi; B Guilbert; T Ternynck; S Avrameas
Journal: Ann N Y Acad Sci Date: 1986 Impact factor: 5.691

3. Is nebulin the defective gene product in Duchenne muscular dystrophy?

Authors: D S Wood; M Zeviani; A Prelle; E Bonilla; G Salviati; A F Miranda; S DiMauro; L P Rowland
Journal: N Engl J Med Date: 1987-01-08 Impact factor: 91.245

4. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors: H Towbin; T Staehelin; J Gordon
Journal: Proc Natl Acad Sci U S A Date: 1979-09 Impact factor: 11.205

5. Muscular dystrophy: mapping the disease phenotype.

Authors: M Robertson
Journal: Nature Date: 1987 Jun 4-10 Impact factor: 49.962

6. Naturally occurring autoantibodies to skeletal proteins from human red blood cells.

Authors: H U Lutz; G Wipf
Journal: J Immunol Date: 1982-04 Impact factor: 5.422

7. Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent.

Authors: J Carlsson; H Drevin; R Axén
Journal: Biochem J Date: 1978-09-01 Impact factor: 3.857

Immunological identification of a high molecular weight protein as a candidate for the product of the Duchenne muscular dystrophy gene.

1. Subcellular fractionation of dystrophin to the triads of skeletal muscle.

2. Natural autoantibodies constitute a substantial part of normal circulating immunoglobulins.

3. Is nebulin the defective gene product in Duchenne muscular dystrophy?

4. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

5. Muscular dystrophy: mapping the disease phenotype.

6. Naturally occurring autoantibodies to skeletal proteins from human red blood cells.

7. Protein thiolation and reversible protein-protein conjugation. N-Succinimidyl 3-(2-pyridyldithio)propionate, a new heterobifunctional reagent.

8. A physiological role for titin and nebulin in skeletal muscle.

9. A comparative study of high molecular weight proteins in various types of muscle across the animal kingdom.

10. Antibodies to tubulin in normal nonimmunized animals.

Review 1. The dystrophin superfamily: variability and complexity.