Divya Sabapathy1, Jelena Klawitter2, Lori Silveira3, Ludmila Khailova4, Max B Mitchell5, Gareth J Morgan4, Michael V DiMaria4, Mark Twite2, Benjamin S Frank4, Jesse A Davidson6. 1. University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. 2. University of Colorado Denver Department of Anesthesiology, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. 3. University of Colorado Denver Department of Biostatistics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. 4. Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. 5. University of Colorado Denver Department of Surgery, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. 6. Section of Cardiology, University of Colorado Denver Department of Pediatrics, 13123 East 16th Ave, Box 100, Aurora, CO, 80045, USA. jesse.davidson@childrenscolorado.org.
Abstract
BACKGROUND: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. AIMS: To map changes in the KP induced by infant CPB. METHODS: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. RESULTS: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. CONCLUSIONS: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.
BACKGROUND: Serum kynurenic acid is associated with poor outcomes after infant cardiopulmonary bypass (CPB), but comprehensive mapping of the kynurenine pathway (KP) after CPB has yet to be performed. AIMS: To map changes in the KP induced by infant CPB. METHODS: Compared changes in serum KP metabolites through 48hrs post-op with liquid-chromatography-tandem mass spectrometry. RESULTS: Infant CPB results in marked increase in proximal, but not distal metabolites of the KP. CONCLUSIONS: Infant CPB leads to accumulation of circulating KP metabolites, which have important neurologic and immunologic activities. Thus, further exploration of the KP is warranted in these high-risk infants.
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