Yen-Huai Lin1,2, Hsi-Chung Chen3, Nai-Wei Hsu2,4,5,6, Pesus Chou2, Michael Mu Huo Teng7,8. 1. Department of Medical Imaging, Cheng Hsin General Hospital, 45 Cheng Hsin Street, Taipei, 112, Taiwan. 2. Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan. 3. Department of Psychiatry and Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan. 4. Division of Cardiology, Department of Internal Medicine, National Yang-Ming University Hospital, Yilan, Taiwan. 5. Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. 6. Public Health Bureau, Yilan County, Taiwan. 7. Department of Medical Imaging, Cheng Hsin General Hospital, 45 Cheng Hsin Street, Taipei, 112, Taiwan. mhteng@gmail.com. 8. Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan. mhteng@gmail.com.
Abstract
INTRODUCTION: There is a need for a cost-effective method to identify individuals with a high risk of osteoporosis. This study aimed to investigate the suitability of hand grip strength in predicting the risk of osteoporosis in Asian adults. MATERIALS AND METHODS: In this cross-sectional, hospital-based study of 1007 participants, the bone mineral density of the spine and hips was evaluated using dual-energy X-ray absorptiometry according to the 2019 International Society for Clinical Densitometry official positions. Bone microarchitecture was evaluated using the trabecular bone score, and hand grip strength was measured in the dominant hand using a hand digital dynamometer. RESULTS: Hand grip strength was significantly related to bone density and bone microarchitecture. Moreover, hand grip strength was a significant predictor of osteoporosis in both women and men. For osteoporosis prediction in women, a threshold of 21.9 kg of hand grip strength had a sensitivity of 59%, specificity of 59%, and area under the curve (AUC) of 0.61. In men, a threshold of 28.7 kg had a sensitivity of 66%, specificity of 78%, and AUC of 0.75. The optimal cutoff strengths for osteoporosis depended on age and sex. CONCLUSION: The measurement of hand grip strength is a simple, cost-effective and an easy assessment method for identifying individuals at a high risk of osteoporosis. The cutoff strength for evaluating osteoporosis in adults is age and sex specific.
INTRODUCTION: There is a need for a cost-effective method to identify individuals with a high risk of osteoporosis. This study aimed to investigate the suitability of hand grip strength in predicting the risk of osteoporosis in Asian adults. MATERIALS AND METHODS: In this cross-sectional, hospital-based study of 1007 participants, the bone mineral density of the spine and hips was evaluated using dual-energy X-ray absorptiometry according to the 2019 International Society for Clinical Densitometry official positions. Bone microarchitecture was evaluated using the trabecular bone score, and hand grip strength was measured in the dominant hand using a hand digital dynamometer. RESULTS: Hand grip strength was significantly related to bone density and bone microarchitecture. Moreover, hand grip strength was a significant predictor of osteoporosis in both women and men. For osteoporosis prediction in women, a threshold of 21.9 kg of hand grip strength had a sensitivity of 59%, specificity of 59%, and area under the curve (AUC) of 0.61. In men, a threshold of 28.7 kg had a sensitivity of 66%, specificity of 78%, and AUC of 0.75. The optimal cutoff strengths for osteoporosis depended on age and sex. CONCLUSION: The measurement of hand grip strength is a simple, cost-effective and an easy assessment method for identifying individuals at a high risk of osteoporosis. The cutoff strength for evaluating osteoporosis in adults is age and sex specific.
Entities:
Keywords:
Bone microarchitecture; Dual-energy X-ray absorptiometry; Hand grip strength; Osteoporosis; Trabecular bone score