Literature DB >> 32889532

A Study of Universal Severe Acute Respiratory Syndrome Coronavirus 2 RNA Testing Among Residents and Staff in a Large Group of Care Homes in South London.

Agnes Marossy1, Stefan Rakowicz2, Angela Bhan3, Sarah Noon2, Amanda Rees3, Manjinder Virk4, Ayazali Nazafi4, Evie Hay4, Louise de Thomasson4, Christina Windle3, Mark Zuckerman4.   

Abstract

BACKGROUND: Care homes have experienced a high number of coronavirus disease 2019 (COVID-19)-related deaths among residents since the onset of the pandemic. However, up to May 2020, there has been a lack of information about the extent of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among residents and staff in care homes and limited testing in this setting.
METHODS: Combined nose and throat swab testing for SARS-CoV-2 RNA was carried out in 2455 residents and staff across 37 care homes in the London Borough of Bromley across a 3-week period. Results were reported within 24 hours of sample delivery, and data were collected on the presence or absence of symptoms.
RESULTS: Overall, the point prevalence of SARS-CoV-2 infection was 6.5%, with a higher rate in residents (9.0%) than in staff (4.7%). A key finding was the high proportion of asymptomatic infection detected in staff (69%) and residents (51%), with evidence of underdetection of symptoms by care home staff.
CONCLUSIONS: The high proportion of asymptomatic infection combined with underdetection of symptoms by care home staff indicates that offering a test to all residents and staff in care homes with rapid reporting of results would assist accurate identification of infected individuals, facilitating prompt infection prevention and control action.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  COVID-19; Coronavirus; SARS-CoV-2; care homes; diagnostic testing

Mesh:

Substances:

Year:  2021        PMID: 32889532      PMCID: PMC7499645          DOI: 10.1093/infdis/jiaa565

Source DB:  PubMed          Journal:  J Infect Dis        ISSN: 0022-1899            Impact factor:   5.226


  6 in total

1.  Health impact of the first and second wave of COVID-19 and related restrictive measures among nursing home residents: a scoping review.

Authors:  Marjolein E A Verbiest; Annerieke Stoop; Aukelien Scheffelaar; Meriam M Janssen; Leonieke C van Boekel; Katrien G Luijkx
Journal:  BMC Health Serv Res       Date:  2022-07-15       Impact factor: 2.908

2.  Occurrence and transmission potential of asymptomatic and presymptomatic SARS-CoV-2 infections: Update of a living systematic review and meta-analysis.

Authors:  Diana Buitrago-Garcia; Aziz Mert Ipekci; Leonie Heron; Hira Imeri; Lucia Araujo-Chaveron; Ingrid Arevalo-Rodriguez; Agustín Ciapponi; Muge Cevik; Anthony Hauser; Muhammad Irfanul Alam; Kaspar Meili; Eric A Meyerowitz; Nirmala Prajapati; Xueting Qiu; Aaron Richterman; William Gildardo Robles-Rodriguez; Shabnam Thapa; Ivan Zhelyazkov; Georgia Salanti; Nicola Low
Journal:  PLoS Med       Date:  2022-05-26       Impact factor: 11.613

3.  Epidemiology and clinical features of COVID-19 outbreaks in aged care facilities: A systematic review and meta-analysis.

Authors:  Mohammad Rashidul Hashan; Nicolas Smoll; Catherine King; Hannah Ockenden-Muldoon; Jacina Walker; Andre Wattiaux; Julieanne Graham; Robert Booy; Gulam Khandaker
Journal:  EClinicalMedicine       Date:  2021-03-01

4.  The challenge of asymptomatic SARS-CoV-2 transmission in care homes.

Authors:  Joël Belmin; Carmelo Lafuente-Lafuente
Journal:  Lancet Reg Health Eur       Date:  2021-02-25

5.  Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis.

Authors:  Qiuyue Ma; Jue Liu; Qiao Liu; Liangyu Kang; Runqing Liu; Wenzhan Jing; Yu Wu; Min Liu
Journal:  JAMA Netw Open       Date:  2021-12-01

6.  Validation of a rapid, saliva-based, and ultra-sensitive SARS-CoV-2 screening system for pandemic-scale infection surveillance.

Authors:  Robert E Dewhurst; Tatjana Heinrich; Paul Watt; Paul Ostergaard; Jose M Marimon; Mariana Moreira; Philip E Houldsworth; Jack D Rudrum; David Wood; Sulev Kõks
Journal:  Sci Rep       Date:  2022-04-08       Impact factor: 4.379

  6 in total

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