| Literature DB >> 32888966 |
Yamato Sajiki1, Satoru Konnai2, Tomohiro Okagawa3, Naoya Maekawa4, Hayato Nakamura5, Yukinari Kato6, Yasuhiko Suzuki7, Shiro Murata8, Kazuhiko Ohashi9.
Abstract
Bovine leukemia virus (BLV) infection is a bovine chronic infection caused by BLV, a member of the genus Deltaretrovirus. In this study, we examined the immunomodulatory effects of GS-9620, a toll-like receptor (TLR) 7 agonist, in cattle (Bos taurus) and its therapeutic potential for treating BLV infection. GS-9620 induced cytokine production in peripheral blood mononuclear cells (PBMCs) as well as CD80 expression in CD11c+ cells and increased CD69 and interferon (IFN)-γ expressions in T cells. Removing CD11c+ cells from PBMCs decreased CD69 expression in T cells in the presence of GS-9620. These results suggest that TLR7 agonism promotes T-cell activation via CD11c+ cells. Analyses using PBMCs from BLV-infected cattle revealed that TLR7 expression in CD11c+ cells was upregulated during late-stage BLV infection. Furthermore, GS-9620 increased IFN-γ and TNF-α production and inhibited syncytium formation in vitro, suggesting that GS-9620 may be used to treat BLV infection.Entities:
Keywords: Anti-PD-L1 antibody; Bovine leukemia virus; CD11c(+) cell; Cattle; T cell; TLR7 agonist
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Year: 2020 PMID： 32888966 DOI： 10.1016/j.dci.2020.103847
Source DB: PubMed Journal: Dev Comp Immunol ISSN： 0145-305X Impact factor: 3.636