Meicheng Yang1, Chengyu Liu1, Xingyao Wang1, Yuwen Li1, Hongxiang Gao1, Xing Liu2, Jianqing Li1,3. 1. The State Key Laboratory of Bioelectronics, School of Instrument Science and Engineering, Southeast University, Nanjing, China. 2. Department of Anesthesiology, The third Xiangya Hospital, Central South University, Changsha, China. 3. School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing, China.
Abstract
OBJECTIVES: Early detection of sepsis is critical in clinical practice since each hour of delayed treatment has been associated with an increase in mortality due to irreversible organ damage. This study aimed to develop an explainable artificial intelligence model for early predicting sepsis by analyzing the electronic health record data from ICU provided by the PhysioNet/Computing in Cardiology Challenge 2019. DESIGN: Retrospective observational study. SETTING: We developed our model on the shared ICUs publicly data and verified on the full hidden populations for challenge scoring. PATIENTS: Public database included 40,336 patients' electronic health records sourced from Beth Israel Deaconess Medical Center (hospital system A) and Emory University Hospital (hospital system B). A total of 24,819 patients from hospital systems A, B, and C (an unidentified hospital system) were sequestered as full hidden test sets. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 168 features were extracted on hourly basis. Explainable artificial intelligence sepsis predictor model was trained to predict sepsis in real time. Impact of each feature on hourly sepsis prediction was explored in-depth to show the interpretability. The algorithm demonstrated the final clinical utility score of 0.364 in this challenge when tested on the full hidden test sets, and the scores on three separate test sets were 0.430, 0.422, and -0.048, respectively. CONCLUSIONS: Explainable artificial intelligence sepsis predictor model achieves superior performance for predicting sepsis risk in a real-time way and provides interpretable information for understanding sepsis risk in ICU.
OBJECTIVES: Early detection of sepsis is critical in clinical practice since each hour of delayed treatment has been associated with an increase in mortality due to irreversible organ damage. This study aimed to develop an explainable artificial intelligence model for early predicting sepsis by analyzing the electronic health record data from ICU provided by the PhysioNet/Computing in Cardiology Challenge 2019. DESIGN: Retrospective observational study. SETTING: We developed our model on the shared ICUs publicly data and verified on the full hidden populations for challenge scoring. PATIENTS: Public database included 40,336 patients' electronic health records sourced from Beth Israel Deaconess Medical Center (hospital system A) and Emory University Hospital (hospital system B). A total of 24,819 patients from hospital systems A, B, and C (an unidentified hospital system) were sequestered as full hidden test sets. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A total of 168 features were extracted on hourly basis. Explainable artificial intelligence sepsis predictor model was trained to predict sepsis in real time. Impact of each feature on hourly sepsis prediction was explored in-depth to show the interpretability. The algorithm demonstrated the final clinical utility score of 0.364 in this challenge when tested on the full hidden test sets, and the scores on three separate test sets were 0.430, 0.422, and -0.048, respectively. CONCLUSIONS: Explainable artificial intelligence sepsis predictor model achieves superior performance for predicting sepsis risk in a real-time way and provides interpretable information for understanding sepsis risk in ICU.
Authors: Jae Kwan Kim; Wonbin Ahn; Sangin Park; Soo-Hong Lee; Laehyun Kim Journal: Int J Environ Res Public Health Date: 2022-02-18 Impact factor: 3.390
Authors: Dabei Cai; Tingting Xiao; Ailin Zou; Lipeng Mao; Boyu Chi; Yu Wang; Qingjie Wang; Yuan Ji; Ling Sun Journal: Front Cardiovasc Med Date: 2022-09-07