Literature DB >> 32882426

Exercise Training Reverses Gut Dysbiosis in Patients With Biopsy-Proven Nonalcoholic Steatohepatitis: A Proof of Concept Study.

Alexa Hughes1, Jessica Dahmus2, Gloriany Rivas2, Breianna Hummer2, Jeremy R Chen See3, Justin R Wright3, Regina Lamendella4, Kathryn H Schmitz5, Christopher Sciamanna6, Mack Ruffin7, Andrew D Patterson8, Rohit Loomba9, Jonathan G Stine10.   

Abstract

Nonalcoholic fatty liver disease is the leading cause of liver disease worldwide and can progress to nonalcoholic steatohepatitis (NASH) through physical inactivity and gut dysbiosis.1 Exercise training reverses gut dysbiosis in non-NASH persons with obesity and in NASH animal models.2,3 Consequently, we conducted a proof-of-concept study investigating the effect of exercise training on gut dysbiosis in NASH patients.
Copyright © 2021 AGA Institute. Published by Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32882426      PMCID： PMC9067391          DOI： 10.1016/j.cgh.2020.08.063

Source DB:  PubMed          Journal:  Clin Gastroenterol Hepatol        ISSN： 1542-3565            Impact factor:   13.576


  7 in total

Review 1.  Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis.

Authors:  Anna M Diehl; Christopher Day
Journal:  N Engl J Med       Date:  2017-11-23       Impact factor: 91.245

2.  Exercise Attenuates Ribosomal Protein Six Phosphorylation in Fatty Liver Disease.

Authors:  Jonathan G Stine; Dandan Xu; Kathryn Schmitz; Christopher Sciamanna; Scot R Kimball
Journal:  Dig Dis Sci       Date:  2020-04-01       Impact factor: 3.199

3.  Effects of exercise and diet interventions on obesity-related sleep disorders in men: study protocol for a randomized controlled trial.

Authors:  Xiao Tan; Antti Saarinen; Tuija M Mikkola; Jarkko Tenhunen; Samu Martinmäki; Aki Rahikainen; Shumei Cheng; Niklas Eklund; Satu Pekkala; Petri Wiklund; Eveliina Munukka; Xinfei Wen; Fengyu Cong; Xi Wang; Yajun Zhang; Ina Tarkka; Yining Sun; Markku Partinen; Markku Alen; Sulin Cheng
Journal:  Trials       Date:  2013-07-26       Impact factor: 2.279

4.  Beneficial effects of exercise on gut microbiota functionality and barrier integrity, and gut-liver crosstalk in an in vivo model of early obesity and non-alcoholic fatty liver disease.

Authors:  Sara Carbajo-Pescador; David Porras; María Victoria García-Mediavilla; Susana Martínez-Flórez; María Juarez-Fernández; María José Cuevas; José Luis Mauriz; Javier González-Gallego; Esther Nistal; Sonia Sánchez-Campos
Journal:  Dis Model Mech       Date:  2019-04-30       Impact factor: 5.758

5.  Nonalcoholic steatohepatitis Fitness Intervention in Thrombosis (NASHFit): Study protocol for a randomized controlled trial of a supervised aerobic exercise program to reduce elevated clotting risk in patients with NASH.

Authors:  Jonathan G Stine; Ian Schreibman; Seyedehsan Navabi; Mitchell Kang; Jessica Dahmus; Christopher Soriano; Gloriany Rivas; Breianna Hummer; Megan Beyer; Heather Tressler; Scot R Kimball; Andrew D Patterson; Kathryn Schmitz; Christopher Sciamanna
Journal:  Contemp Clin Trials Commun       Date:  2020-04-04

6.  Changes of intestinal bacterial microbiota in coronary heart disease complicated with nonalcoholic fatty liver disease.

Authors:  Yiwen Zhang; Jun Xu; Xuemei Wang; Xinhua Ren; Yulan Liu
Journal:  BMC Genomics       Date:  2019-11-14       Impact factor: 3.969

7.  Non-alcoholic fatty liver and the gut microbiota.

Authors:  Stavros Bashiardes; Hagit Shapiro; Shachar Rozin; Oren Shibolet; Eran Elinav
Journal:  Mol Metab       Date:  2016-06-14       Impact factor: 7.422
  7 in total
  2 in total

Review 1.  Clinical practice advice on lifestyle modification in the management of nonalcoholic fatty liver disease in Japan: an expert review.

Authors:  Yoshihiro Kamada; Hirokazu Takahashi; Masahito Shimizu; Takumi Kawaguchi; Yoshio Sumida; Hideki Fujii; Yuya Seko; Shinya Fukunishi; Katsutoshi Tokushige; Atsushi Nakajima; Takeshi Okanoue
Journal:  J Gastroenterol       Date:  2021-10-31       Impact factor: 7.527

Review 2.  Bile acids and the gut microbiota: metabolic interactions and impacts on disease.

Authors:  Stephanie L Collins; Jonathan G Stine; Jordan E Bisanz; C Denise Okafor; Andrew D Patterson
Journal:  Nat Rev Microbiol       Date:  2022-10-17       Impact factor: 78.297
  2 in total

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