Xin Xiong1, Wei Xia1, Yuanyuan Li1, Shunqing Xu1, Yaqi Zhang2. 1. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. 2. Wuhan Medical and Healthcare Center for Women and Children, Wuhan, Hubei, China.
Abstract
OBJECTIVE: This study aimed to estimate the associations of gestational weight gain rate (GWGR) during different trimesters with offspring growth and overweight/obesity risk. METHODS: The study included 4,807 mother-infant pairs enrolled in Wuhan, China. GWGR in each trimester was used as a continuous and a categorical variable to estimate the associations with offspring BMI z score (ZBMI) and overweight/obesity risk between 0 and 2 years. RESULTS: Greater GWGR (per 0.2 kg/wk) in the first, second, and third trimester was positively associated with offspring ZBMI across birth to 2 years old (β 0.06 [95% CI: 0.04-0.09], β 0.13 [95% CI: 0.09-0.16], and β 0.04 [95% CI: 0.02-0.07], respectively). Excessive GWGR in the first trimester (≥ 0.30 kg/wk) was associated with an odds ratio (OR) of 1.58 (95% CI: 1.18-2.13) and 1.37 (95% CI: 1.11-1.71) for macrosomia and 2-year overweight/obesity, respectively. Excessive GWGR in the second trimester was associated with an OR of 2.09 (95% CI: 1.42-3.08), 1.21 (95% CI: 1.02-1.43), and 1.48 (95% CI: 1.15-1.90) for macrosomia, 1-year, and 2-year overweight/obesity, respectively. Excessive GWGR in the third trimester was associated with an OR of 1.91 (95% CI: 1.27-2.86) and 1.32 (95% CI: 1.02-1.72) for macrosomia and 2-year overweight/obesity, respectively. CONCLUSIONS: Excessive GWGR in each trimester was positively associated with offspring ZBMI and early-childhood overweight/obesity risk.
OBJECTIVE: This study aimed to estimate the associations of gestational weight gain rate (GWGR) during different trimesters with offspring growth and overweight/obesity risk. METHODS: The study included 4,807 mother-infant pairs enrolled in Wuhan, China. GWGR in each trimester was used as a continuous and a categorical variable to estimate the associations with offspring BMI z score (ZBMI) and overweight/obesity risk between 0 and 2 years. RESULTS: Greater GWGR (per 0.2 kg/wk) in the first, second, and third trimester was positively associated with offspring ZBMI across birth to 2 years old (β 0.06 [95% CI: 0.04-0.09], β 0.13 [95% CI: 0.09-0.16], and β 0.04 [95% CI: 0.02-0.07], respectively). Excessive GWGR in the first trimester (≥ 0.30 kg/wk) was associated with an odds ratio (OR) of 1.58 (95% CI: 1.18-2.13) and 1.37 (95% CI: 1.11-1.71) for macrosomia and 2-year overweight/obesity, respectively. Excessive GWGR in the second trimester was associated with an OR of 2.09 (95% CI: 1.42-3.08), 1.21 (95% CI: 1.02-1.43), and 1.48 (95% CI: 1.15-1.90) for macrosomia, 1-year, and 2-year overweight/obesity, respectively. Excessive GWGR in the third trimester was associated with an OR of 1.91 (95% CI: 1.27-2.86) and 1.32 (95% CI: 1.02-1.72) for macrosomia and 2-year overweight/obesity, respectively. CONCLUSIONS: Excessive GWGR in each trimester was positively associated with offspring ZBMI and early-childhood overweight/obesity risk.
Authors: Sisi Li; Yuhan Qiu; Xi Yuan; Qin Zhang; Mark D Kilby; Richard Saffery; Philip N Baker; Li Wen; Chao Tong; Hongbo Qi Journal: Front Pediatr Date: 2022-08-02 Impact factor: 3.569