Literature DB >> 32878471

Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment.

Federico Di Tizio1, Irene Gattazzo1, Federico Di Staso1, Mariachiara Di Pippo1, Fabio Guglielmelli1, Gianluca Scuderi1.   

Abstract

PURPOSE: To present a modified surgical technique, based on a combination of human amniotic membrane (hAM) patch and autologous Platelet-rich plasma (PRP) in a case of recurrent retinal detachment (RRD) due to a perivascular retinal hole over an area of staphyloma in an eye with pathologic myopia.
METHODS: Presenting the surgical technique with the disposal of surgical video. After performing 23-gauge pars plana vitrectomy (PPV) the hAM patch was inserted under the neuroretina through the perivascular hole and PRP was injected on top to speed up the closure of the hole. To complete the surgical procedure High Viscosity Silicon oil (5000cst) was used as tamponade. The patient was prescribed to maintain a face-down position for the first 3 days after the operation. Follow-up was evaluated through Optical coherence tomography (OCT) scans.
RESULTS: The 3 days postoperative OCT showed a flat retina with the filling of the myopic staphyloma. The hAM patch was well positioned and the retinal hole could not be identified. At 6 weeks from intervention, the site of the retinal hole at OCT scan was covered by new tissue. Silicone oil was removed 3 months later with no recurrence.
CONCLUSION: hAM transplantation is a novel technique in case of retinal detachment recurrences to seal retinal holes over high myopic chorioretinal atrophy. The adjunctive use of PRP and high viscosity silicon oil allows to reducing the standard face-down positioning timing, representing a valid solution for elderly patients who have difficulties maintaining the position for long periods.

Entities:  

Keywords:  Human amniotic membrane; optical coherence tomography; pars plana vitrectomy; pathological myopia; platelet-rich plasma; recurrent retinal detachment; retinal hole; vitreoretinal surgery

Mesh:

Year:  2020        PMID: 32878471     DOI: 10.1177/1120672120953314

Source DB:  PubMed          Journal:  Eur J Ophthalmol        ISSN: 1120-6721            Impact factor:   2.597


  1 in total

Review 1.  Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge.

Authors:  Hoda Elkhenany; Azza El-Derby; Mohamed Abd Elkodous; Radwa A Salah; Ahmed Lotfy; Nagwa El-Badri
Journal:  Stem Cell Res Ther       Date:  2022-01-10       Impact factor: 6.832

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.