Ruifang Yuan1, Dingkun Zhang1, Jinhui Yang2, Zhenfeng Wu3, Chuanhong Luo1, Li Han1, Fangli Yang4, Junzhi Lin5, Ming Yang6. 1. Pharmacy School, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, PR China. 2. Sichuan Baicao Jinggong Biotechnology Co., Ltd., Chengdu, 610000, PR China. 3. Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, PR China. 4. Sinopharm Sichuan Orthopedic Tehnology & Equipment Co., Ltd., Chengdu, 610000, PR China. 5. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, PR China; School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 610072, PR China. Electronic address: linjunzhi@cdutcm.edu.cn. 6. Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, PR China. Electronic address: 20050858@jxutcm.edu.cn.
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Migraines have become a major threat to human health, as they significantly affect human health and quality of life due to a high prevalence rate, attack rate and pain intensity. Aromatherapy, with its comfortable and pleasant natural characteristics and rapid and efficient characteristics, is widely favored by patients in the folk. Chinese folk also have the application history and related records of aromatic plants in the treatment of migraine. AIM OF THE STUDY: This study was conducted to review the pathogenesis of migraine, the application of plant essential oils in the treatment of migraine, and further explore the material basis and mechanism of action of plant essential oils against migraine. MATERIALS AND METHODS: Search the electronic literature of essential oils with anti-migraine effect in Google Scholar, PubMed and China National Knowledge Infrastructure, and further search the research situation of the monomer components of essential oils in migraine, inflammation, pain and other aspects. RESULTS: studies show that there are 10 types of plant essential oils that could relieve migraine symptoms, and that 16 monomers may play a role in migraine treatment by effectively inhibiting neurogenic inflammation, hyperalgesia and balancing vasorelaxation. CONCLUSION: Aromatic plant essential oils can relieve migraine effectively, these findings can be used as an important part of the development of anti-migraine drugs.
ETHNOPHARMACOLOGICAL RELEVANCE: Migraines have become a major threat to human health, as they significantly affect human health and quality of life due to a high prevalence rate, attack rate and pain intensity. Aromatherapy, with its comfortable and pleasant natural characteristics and rapid and efficient characteristics, is widely favored by patients in the folk. Chinese folk also have the application history and related records of aromatic plants in the treatment of migraine. AIM OF THE STUDY: This study was conducted to review the pathogenesis of migraine, the application of plant essential oils in the treatment of migraine, and further explore the material basis and mechanism of action of plant essential oils against migraine. MATERIALS AND METHODS: Search the electronic literature of essential oils with anti-migraine effect in Google Scholar, PubMed and China National Knowledge Infrastructure, and further search the research situation of the monomer components of essential oils in migraine, inflammation, pain and other aspects. RESULTS: studies show that there are 10 types of plant essential oils that could relieve migraine symptoms, and that 16 monomers may play a role in migraine treatment by effectively inhibiting neurogenic inflammation, hyperalgesia and balancing vasorelaxation. CONCLUSION: Aromatic plant essential oils can relieve migraine effectively, these findings can be used as an important part of the development of anti-migraine drugs.
Authors: Yuri G Figueiredo; Eduardo A Corrêa; Afonso H de Oliveira Junior; Ana C D C Mazzinghy; Henrique D O P Mendonça; Yan J G Lobo; Yesenia M García; Marcelo A D S Gouvêia; Ana C C F F de Paula; Rodinei Augusti; Luisa D C B Reina; Carlos H da Silveira; Leonardo H F de Lima; Júlio O F Melo Journal: Molecules Date: 2022-03-01 Impact factor: 4.411