Bruno Shigueo Yonekura Inada1,2, Thiago Junqueira Ribeiro Rezende3, Fernando Vieira Pereira4, Lucas Ávila Lessa Garcia5, Antônio José da Rocha6, Pedro Braga Neto7,8, Orlando Graziani Povoas Barsottini4, Marcondes Cavalcante França3, José Luiz Pedroso4. 1. Division of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. brunosy.inada@gmail.com. 2. Department of Neuroradiology, Hospital Beneficência Portuguesa, São Paulo, Brazil. brunosy.inada@gmail.com. 3. Department of Neurology, State University of Campinas (UNICAMP), São Paulo, Brazil. 4. Division of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. 5. Department of Neuroradiology, University of São Paulo (USP), São Paulo, Brazil. 6. Department of Neuroradiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil. 7. Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil. 8. Center of Health Sciences, Universidade Estadual do Ceará, Ceará, Brazil.
Abstract
PURPOSE: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. METHODS: We assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores). RESULTS: Two different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40-0.59). CONCLUSION: DTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease.
PURPOSE: The aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities. METHODS: We assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores). RESULTS: Two different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40-0.59). CONCLUSION: DTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease.
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Authors: Kristen H Schuster; Annie J Zalon; Hongjiu Zhang; Danielle M DiFranco; Nicholas R Stec; Zaid Haque; Kate G Blumenstein; Amanda M Pierce; Yuanfang Guan; Henry L Paulson; Hayley S McLoughlin Journal: J Neurosci Date: 2022-01-18 Impact factor: 6.709