Theresa Lüth1, Inke R König2, Anne Grünewald1,3, Meike Kasten1, Christine Klein1, Faycel Hentati4, Matthew Farrer5, Joanne Trinh1. 1. Institute of Neurogenetics, University of Lübeck, Lübeck, Germany. 2. Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany. 3. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg. 4. Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia. 5. Department of Neurology, University of Florida, Gainesville, Florida, USA.
Abstract
OBJECTIVES: The effect of environmental and lifestyle factors on patients with LRRK2 (leucine-rich repeat kinase 2) p.Gly2019Ser (LRRK2+ /PD+ ) compared to idiopathic PD (iPD) has yet to be thoroughly investigated. METHODS: In a homogeneous Tunisian Arab Berber population, we recruited 200 idiopathic PD and 199 LRRK2 p.Gly2019Ser mutation carriers, of whom 142 had PD (LRRK2+ /PD+ ) and 57 were unaffected (LRRK2+ /PD- ). Case report form (CRF) questionnaires (motor and non-motor symptoms) including the Geoparkinson Questionnaire were used to assess environmental and lifestyle factors. RESULTS: In LRRK2+ /PD+ , tobacco use was significantly associated with a later median age at onset (AAO). The median AAO was 60 years (interquartile range = 52-67.25) for tobacco users, compared to 52 years (interquartile range = 45.25-61) for non-users (P = 0.0042 at adjusted α = 0.025). Additionally, we observed an independent but additive effect of black tea consumption and tobacco use. CONCLUSIONS: Our data suggest that tobacco and black tea have a protective effect on age at onset in LRRK2+ /PD+ .
OBJECTIVES: The effect of environmental and lifestyle factors on patients with LRRK2 (leucine-rich repeat kinase 2) p.Gly2019Ser (LRRK2+ /PD+ ) compared to idiopathic PD (iPD) has yet to be thoroughly investigated. METHODS: In a homogeneous Tunisian Arab Berber population, we recruited 200 idiopathic PD and 199 LRRK2 p.Gly2019Ser mutation carriers, of whom 142 had PD (LRRK2+ /PD+ ) and 57 were unaffected (LRRK2+ /PD- ). Case report form (CRF) questionnaires (motor and non-motor symptoms) including the Geoparkinson Questionnaire were used to assess environmental and lifestyle factors. RESULTS: In LRRK2+ /PD+ , tobacco use was significantly associated with a later median age at onset (AAO). The median AAO was 60 years (interquartile range = 52-67.25) for tobacco users, compared to 52 years (interquartile range = 45.25-61) for non-users (P = 0.0042 at adjusted α = 0.025). Additionally, we observed an independent but additive effect of black tea consumption and tobacco use. CONCLUSIONS: Our data suggest that tobacco and black tea have a protective effect on age at onset in LRRK2+ /PD+ .
Authors: Martin Lang; Anne Grünewald; Peter P Pramstaller; Andrew A Hicks; Irene Pichler Journal: Cell Mol Life Sci Date: 2022-05-05 Impact factor: 9.207
Authors: Steven R Bentley; Ilaria Guella; Holly E Sherman; Hannah M Neuendorf; Alex M Sykes; Javed Y Fowdar; Peter A Silburn; Stephen A Wood; Matthew J Farrer; George D Mellick Journal: Genes (Basel) Date: 2021-03-17 Impact factor: 4.096